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What causes simian crease? 5 possible conditions

What Is a Simian Crease?

“Simian crease” is an outdated term that is no longer considered politically correct; “simian” refers to an ape or monkey, or something having the characteristics of these animals. Single transverse palmar crease (STPC) is a more accurate name for this condition.

The skin of a normal palm has three large creases. The distal transverse palmar crease runs near the top of palm and begins close to the little finger. The thenar transverse crease is the lowest on the palm and appears to run almost vertically. The proximal transverse palmar crease lies between the other two creases.

In cases of SPTC, the distal and proximal creases are not present. Instead, they combine to form one transverse palmar crease. The thenar transverse crease remains the same.

STPC occurs in about one in 30 individuals, and males are twice as likely to have this condition as females. Sometimes, STPC is a symptom of disorders such as Down syndrome, or may be an early indicator of developmental problems. However, this is usually not the case.

Causes of a Simian Crease

STPC develops while a baby is growing in the mother’s womb, during the first trimester, when palm creases develop.

SPTC may be idiopathic (without an identifiable cause). The condition is relatively common, and most individuals with SPTC are perfectly healthy and have no underlying conditions. However, for others, having a STPC may be a warning sign of an undiagnosed condition.

Disorders a Simian Crease May Indicate

STPC can be a valuable symptom in the early diagnosis of a number of disorders. The most well known disorder of which STPC is a symptom is Down syndrome. Down syndrome is a developmental disorder that results most often from an extra genetic copy of chromosome 21.

Disorders of which STPC is a diagnostic sign include:

  • Turner’s syndrome: All humans have 46 chromosomes, two of which are sex chromosomes. For a boy, the sex chromosomes are XY, and for a girl, they are XX. In the case of Turner’s syndrome, a girl is born with only one X chromosome. The disorder causes incomplete sexual and physical development.
  • Aarskog syndrome: An inherited (passed down through families) genetic condition that is linked to the X chromosome. The syndrome affects a person’s facial features, skeleton, and muscle development.
  • Klinefelter’s syndrome: A genetic disorder in which a male has an extra copy of the X chromosome (XXY instead of XY). Patients grow up with many female characteristics.
  • fetal alcohol syndrome (FAS): This syndrome appears in children whose mothers drank during pregnancy. The alcohol damage may cause developmental delays and stunted growth. Children may also suffer from heart problems (arrhythmias, ventricular tachycardia, etc.).

Complications of a Simian Crease

Unless it is associated with another condition, such as Down syndrome, STPC does not indicate any medical problem. In one reported case, STPC was associated with fused carpal bones in the hand. Fused carpal bones can be related to many syndromes, and can lead to hand pain, a greater likelihood of hand fractures, and arthritis (Suresh, 2011).

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See a list of possible causes in order from the most common to the least.


Down Syndrome

Down syndrome is the most common genetic condition in the United States. It causes physical and mental developmental delays and disabilities.

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Aarskog Syndrome

Aarskog syndrome is a very rare genetic disorder caused by a mutation on the X-chromosome that can affect a child's stature, facial features, genitalia, muscles, and bones. It primarily affects males.

Read more »


Turner Syndrome (Monosomy X)

The human body typically contains 46 chromosomes, which store your genetic material. The X and Y sex chromosomes determine your gender. Males have one X and one Y chromosome, while females have two X chromosomes. Turne...

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Fetal Alcohol Syndrome

Fetal alcohol syndrome (FAS) occurs when a baby is born with varied mental and physical defects due to the mother consuming alcohol during pregnancy.

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Crying Cat Syndrome (Cri-du-Chat)

Crying cat syndrome, also called Cri-du-chat or 5P syndrome, is a genetic condition where your baby is born with a deletion on the short arm of chromosome 5. The condition is rare and occurs in only about 1 in 20,000 t...

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.