Irritable mood, Tired: 26 Possible Causes
Let's see if we can figure out what's causing your symptoms.
Select additional symptoms and we'll narrow your results.

What causes irritable mood and tired? 26 possible conditions

See a list of possible causes in order from the most common to the least.



Sleeplessness, or insomnia, is a serious sleep disorder. It can mean the inability to fall asleep or stay asleep throughout the night, or the tendency to wake too early before having gotten enough sleep.

Read more »



Learn more about anxiety with this overview of anxiety disorders.

Read more »



There are many symptoms of HIV/AIDS, including persistent skin rashes, night sweats, and mouth sores.

Read more »


Generalized Anxiety Disorder

People who suffer from generalized anxiety disorder, or GAD, worry uncontrollably about common occurrences and situations. The condition may also be called chronic anxiety neurosis.GAD is different than normal feeling...

Read more »


Acute Stress Disorder

Acute stress disorder (ASD) may develop after a traumatic event, and it can last up to one month. Learn about the symptoms of ASD.

Read more »


CFS (Chronic Fatigue Syndrome)

Chronic fatigue syndrome (CFS) is a debilitating disorder characterized by extreme tiredness that can't be explained by an underlying medical condition.

Read more »


Low Blood Sugar (Hypoglycemia)

This condition is considered a medical emergency. Urgent care may be required.

Hypoglycemia, or low blood sugar, is a potentially dangerous condition that's most common in people with diabetes. Learn what causes it and how to prevent it.

Read more »



This condition is considered a medical emergency. Urgent care may be required.

A concussion is a mild traumatic brain injury. Usually it occurs after an impact to your head or after a whiplash-type injury. A concussion can cause many severe symptoms that affect brain function.

Read more »


Iron Deficiency Anemia

Iron-deficiency anemia is the most common type of anemia, which occurs when the body does not have enough of the mineral iron. The body needs iron to produce hemoglobin.

Read more »


PMS (Premenstrual Syndrome)

Premenstrual syndrome causes a wide variety of emotional and physical symptoms. Learn more about it.

Read more »


Postpartum Depression

Postpartum depression affects as many as 13 percent of new mothers. In the U.S., that's half a million women. Learn about symptoms, causes, risks, and more.

Read more »



This condition is considered a medical emergency. Urgent care may be required.

Meningococcemia is a bacterial infection that can lead to meningitis. Learn more about the symptoms.

Read more »


Sinus Infections (Sinusitis)

A sinus infection, or sinusitis, is a common condition that affects 30 million people in the United States each year, according to the National Institute of Allergy and Infectious Diseases. The infection occurs whe...

Read more »


Bipolar Disorder

Bipolar disorder is a mental illness marked by extreme shifts in mood ranging from mania to depression. It is also called bipolar disease or manic depression.

Read more »


Diabetes Overview

Diabetes is a group of chronic metabolic diseases caused by defects in insulin production or function. Advanced diabetes may cause stomach pain, nausea, dizziness, and cramps.

Read more »


Cocaine and related disorders

According to the National Institute on Drug Abuse, about 15 percent of people in the U.S. have tried cocaine. Find out more about the effects of addiction.

Read more »


Graves' Disease

Graves' disease is an autoimmune disorder that causes your thyroid gland to create too much thyroid hormone. Learn the symptoms and your treatment options.

Read more »


Migraine with Aura

Migraine is a disorder characterized by repeated attacks of severe headache. Symptoms include throbbing or pulsating pain, usually on only one side of the head, and can last between four hours and three days.

Read more »


Type 1 Diabetes

Type 1 diabetes is a chronic disease that result high levels of glucose in the blood due to a lack of insulin production. Glucose is a natural sugar that your body uses as a source of energy.

Read more »


Lactose Intolerance

Lactose intolerance is the inability to break down a type of natural sugar called lactose. Lactose is commonly found in dairy products, such as milk and yogurt. A person becomes lactose intolerant when his or her smal...

Read more »

This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.