Let's see if we can figure out what's causing your indifferent mood.
Select additional symptoms and we'll narrow your results.

What causes indifferent mood? 15 possible conditions

What Is Apathy?

Apathy is a lack of interest in life activities and/or interacting with others. It can affect a person’s ability to keep a job, maintain personal relationships, and enjoy life.

All people experience apathy from time to time. A person may occasionally feel unmotivated or uninterested in his or her daily tasks. This type of situational apathy is normal. Apathy becomes more dangerous when someone is unmotivated to treat a chronic condition such as diabetes or mental illness.

Apathy is a symptom of a number of neurological disorders, including Alzheimer’s disease. Apathy also can be a syndrome in and of itself.

What Causes Apathy?

Apathy is a symptom of a number of psychiatric and neurological disorders. Examples include:

  • Alzheimer’s disease
  • dysthymia or chronic mild depression
  • frontotemporal dementia
  • Huntington’s disease
  • Parkinson’s disease
  • progressive supranuclear palsy
  • schizophrenia
  • stroke
  • vascular dementia

A person can also experience apathy even without an underlying medical condition.

Doctors have found lesions in the frontal lobe of the brain in patients with apathy symptoms (Ishizaki, J., et al., 2011). This leads researchers to believe that the brain’s apathy center is located in the front of the brain. If a person has a stroke that affects this part of the brain, apathy may result.

Teenagers are likely to experience periods of apathy. This typically passes with time. Long-term emotional detachment and apathy is not normal in teens.

What Are the Symptoms of Apathy?

Apathy sufferers have a lack of passion or motivation.

Apathy affects a person’s behavior and his or her ability to complete daily activities. The main symptom is a lack of motivation to do, complete, or accomplish anything. People with apathy typically have low energy levels.

Emotions, motivation, and willingness to act are often lower or diminished. Activities or events that normally interest a person will create little to no response.

Apathetic people express disinterest in many aspects of life. They are usually indifferent when they meet new people or try new things. They show no interest in activities or in addressing personal problems or concerns. Facial expressions do not seem to change. They exhibit a lack of effort, planning, and emotional response. They tend to spend more time in solitary activities.

Continued apathy affects a person’s ability to maintain personal relationships and perform well at work.

Apathy is not the same as depression, though they share some similar symptoms, such as disinterest. People with depression may also have feelings of hopelessness and guilt. Suicide may be a risk in patients suffering from depression. Apathy sufferers do not have these symptoms.

How Is Apathy Diagnosed?

Healthcare practitioners use four criteria to diagnose apathy. People with apathy meet all four.

  • A decrease in or lack of motivation: A patient displays diminished motivation that is not consistent with his or her age, culture, or health status.
  • Behavior, thinking, or emotional changes: Changes in behavior may make it difficult for patients to engage in conversations or perform daily tasks. Changes in thinking include a disinterest in the news, in tasks that require deeper thinking, or in social events.
  • Affect on quality of life: The changes in behavior negatively affect a person’s professional life, personal relationships, or other facets of life.
  • The changes in behavior are not caused by other conditions: The changes in behavior are unrelated to physical disabilities, substance abuse, or an affected level of consciousness. 

Patients must have these symptoms for four weeks or longer.

How Is Apathy Treated?

Apathy treatments depend upon the underlying cause. Medications and psychotherapy can restore interest in life. However, patients with progressive disorders such as Parkinson’s or Alzheimer’s may show chronic apathy symptoms.


Doctors prescribe medications for apathy according to the underlying condition.

Examples include:

  • antidementia agents, which treat Alzheimer’s disease, such as donepezil (Aricept), galantamine (Razadyne), and rivastigine (Exelon)
  • antidepressants, such as paroxetine (Paxil), sertraline (Zoloft), and bupropion (Wellbutrin, Zyban); a group of antidepressants called SSRIs can make apathy symptoms worse in the elderly
  • cerebral circulation and metabolism stimulants that treat symptoms of stroke, such as nicergoline (Sermion)
  • dopamine stimulants, which treat Parkinson’s disease, such as ropinirole (Requip)
  • antipsychotic agents, which are used to treat schizophrenia
  • psychostimulants, which are often used to treat apathy with no known underlying cause; examples include methylphenidate (Ritalin), pemoline (Cylert), and amphetamine

Home Care

Apathy sufferers benefit from a supportive network of family and/or friends. These support networks can help them regain interest in their surroundings.

Mental health professionals can discuss concerns with patients. They can also help patients re-establish a more positive outlook on life. A combination of therapy and medication is usually more effective for apathy sufferers than each treatment alone (Ishizaki, J., et al., 2011).

Prospective Treatments

Research continues on other potential treatments for chronic apathy. An example is cranial electrotherapy stimulation (Ishizaki, J., et al., 2011). This approach may help patients who suffer from apathy after a traumatic brain injury that affects the frontal lobe. A doctor applies a brief, low-voltage electric current across the forehead to stimulate the brain. The treatment is painless.

Another potential therapy is cognitive stimulation therapy. This approach is used for Alzheimer’s patients. Patients participate in group activities to stimulate brain waves. Examples include games or looking at pictures to recognize facial expressions.

Article Sources:

●      Chow, T. W., Binns, M.A., Cummings, J.L., Lam, I., Black, S.E., Miller, B.L., et al. (2009). Apathy Symptom Profile and Behavioral Associations in Frontotemporal Dementia vs Dementia of Alzheimer Type. Archives of Neurology, 66(7), 888-893.
●      Ishizaki, J. & Mimura. M. (April 2011). Dysthymia and apathy: diagnosis and treatment. Depression Research and Treatment. 2011, 7 pages.
●      Mayo Clinic Study Finds Apathy and Depression Predict Progression from Mild Cognitive Impairment to Dementia (2010, July 12). Mayo Clinic. Retrieved September 12, 2013, from http://www.mayoclinic.org/news2010-rst/5857.html
●      Moretti, R., Torre, P., Esposito, F., Barro, E., Tomietto, P., & Antonello, R. (2013). Apathy as a key symptom in behavior disorders: difference between Alzheimer’s disease and subcortical vascular dementia. Understanding Alzheimer’s Disease. Prof. Inga Zerr (Ed.). InTech. DOI: 10.5772/54264.
●      Mulin, E., Llorca, P., Dessi, B., Nobili, F., Leentjens, A., Delliaux, M., et al. (2010). Diagnostic Criteria For Apathy In Clinical Practice. International Journal of Geriatric Psychiatry, 26, 158-165.
●      Richard, E., Schmand, B., Eikelenboom, P., Yang, S.C., Ligthart, S.A., et al. (2012, May 11). Symptoms of apathy are associated with progression from mild cognitive impairment to Alzheimer’s disease in non-depressed subjects. Dementia Geriatric Cognitive Disorders, 33(2-3), 204-209.
●      Starkstein, S.E., Petracca, G., Chemerinski, E., & Kramer. J. (2001). Syndromic validity of apathy in Alzheimer’s disease. The American Journal of Psychiatry. 158(6). 872-877.

Read More

See a list of possible causes in order from the most common to the least.


Stroke Overview

This condition is considered a medical emergency. Urgent care may be required.

A stroke (a "brain attack") is a medical emergency in which part of the brain is deprived of oxygen. This occurs when an artery that supplies oxygenated blood to the brain becomes damaged and brain cells begin to die.

Read more »


Bipolar Disorder

Bipolar disorder mental illness marked by extreme from mania to depression. Bipolar disorder is also called bipolar disease or manic depression.

Read more »


Intracerebral Hemorrhage

This condition is considered a medical emergency. Urgent care may be required.

Intracerebral hemorrhage (ICH) is when blood suddenly bursts into brain tissue, causing damage to the brain. Symptoms usually appear suddenly during ICH.

Read more »


Borderline Personality Disorder

Borderline personality disorder (BPD) is a mental illness that develops during adolescence or early adulthood. It is marked by a pattern of emotional instability, impulsive behavior, a distorted self-image, and unstabl...

Read more »


Sleep Disorders

Sleep disorders/disturbances can cause your sleep to be disturbed. Disturbed sleep includes the inability to fall asleep, the inability to go back to sleep, and frequent waking up during the night. Sleep disorders ca...

Read more »


Mini Stroke (Transient Ischemic Attack)

This condition is considered a medical emergency. Urgent care may be required.

During a transient ischemic attack (TIA, mini stroke) blood stops flowing to the brain for a short period of time. TIA doesn't kill brain cells like a stroke does. TIA causes symptoms that mimic those of a stroke.

Read more »


Postpartum Depression

Postpartum depression affects as many as 13 percent of new mothers. In the U.S., that's half a million women. Learn about symptoms, causes, risks, and more.

Read more »


Acute Mountain Sickness

Acute mountain sickness (altitude sickness or high altitude pulmonary edema) occurs in high altitudes, especially when exercising. A lack of oxygen can give the skin and lips a blue tinge.

Read more »



Hypercalcemia is a condition in which you have too much calcium in your blood. Serious cases could cause symptoms like abdominal pain, nausea, constipation, and weakness.

Read more »


Post Traumatic Stress Disorder (PTSD)

Post-traumatic stress disorder (PTSD) is an anxiety disorder that occurs after experiencing or witnessing a traumatic event. PTSD can cause disruptive symptoms of panic, increased arousal, and mental/emotional problems.

Read more »


Opioids and related disorders

Opioids are a class of drugs that include both natural and synthetic substances. The natural opioids (referred to as opiates) include opium and morphine.

Read more »


Schizoid Personality Disorder

Schizoid personality disorder is a type of eccentric personality disorder. A person with this disorder has behavior that is different from most other people. For example, people with schizoid personality disorder ten...

Read more »



This condition is considered a medical emergency. Urgent care may be required.

Encephalitis is an inflammation of the brain tissue. It's most often caused by viral infections. In some cases, bacterial infections can cause encephalitis.

Read more »


Meningeal Tuberculosis

Tuberculosis (TB) is a contagious airborne disease that typically affects the lungs. TB is caused by a bacterium called Mycobacterium tuberculosis. If a TB infection is not treated promptly, the bacterium can trave...

Read more »


Tay-Sachs Disease

Tay-Sachs is a disease of the central nervous system; it is a neurodegenerative disorder. Tay-Sachs most commonly affects infants. In infants, it is a progressive disease that is unfortunately always fatal. Rarely...

Read more »

This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.