General weakness, Unintentional weight gain: 13 Possible Causes
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What causes general weakness and unintentional weight gain? 13 possible conditions

See a list of possible causes in order from the most common to the least.



The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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There are many symptoms of HIV/AIDS, including persistent skin rashes, night sweats, and mouth sores.

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Bleeding or spotting, increased need to urinate, tender breasts, fatigue, nausea, and missed period are signs of pregnancy.

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PMS (Premenstrual Syndrome)

Premenstrual syndrome causes a wide variety of emotional and physical symptoms. Learn more about it.

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Gestational Diabetes

During pregnancy, you might develop high levels of blood sugar. Learn how this condition, known as gestational diabetes mellitus, is diagnosed and treated.

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Congestive Heart Failure (CHF)

Congestive heart failure (CHF) is a chronic condition that affects the chambers of your heart. CHF refers to fluid buildup around your heart.

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Cushing Syndrome

Cushing's syndrome occurs due to abnormally high levels of cortisol. The most common cause of it is overuse of corticosteroids. Learn more about this condition.

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Postpartum Depression

Postpartum depression affects as many as 13 percent of new mothers. In the U.S., that's half a million women. Learn about symptoms, causes, risks, and more.

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Hashimoto's Disease

Hashimoto's disease is a condition that damages the thyroid's ability to function properly. It can cause a goiter, or enlarged thyroid, which can make the front of the neck look swollen.

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Bipolar Disorder

Bipolar disorder is a mental illness marked by extreme shifts in mood ranging from mania to depression. It is also called bipolar disease or manic depression.

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Alcoholic Liver Disease

Damage to the liver from excessive drinking can lead to ALD. Years of alcohol abuse cause the liver to become inflamed and swollen. This damage can also cause scarring known as cirrhosis. Cirrhosis is the final stage o...

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Diabetic Nephropathy

Diabetic nephropathy is a type of progressive kidney disease that occurs in people who have type 1 or type 2 diabetes. The University of Washington estimates that 20 to 40 percent of people with diabetes will ge...

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Pituitary Cancer

The pituitary gland is a very small gland of major importance to the functioning of the human body. It is located directly behind the eyes and below the front of the brain. It is about the size of a pea. Despite it...

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.