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What causes general weakness and swollen ankle? 20 possible conditions

See a list of possible causes in order from the most common to the least.



Obesity is defined as having a body mass index (BMI) of 30 or more. BMI is calculated using a person's weight and height. It can lead to other conditions like diabetes, heart disease, and cancer.

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Bleeding or spotting, increased need to urinate, tender breasts, fatigue, nausea, and missed period are signs of pregnancy.

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The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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Congestive Heart Failure (CHF)

Congestive heart failure is a chronic condition that affects the four chambers of the heart. Early symptoms include fatigue and weight gain. Irregular heart beat and wheezing indicate a worsening.

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Nutritional Deficiencies (Malnutrition)

A nutritional deficiency occurs when the body doesn't absorb the necessary amount of a nutrient. Symptoms include a pale complexion, fatigue, hair loss, and depression.

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PMS (Premenstrual Syndrome)

PMS symptoms start five to 11 days before menstruation and typically go away once menstruation begins. The cause of PMS is unknown.

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Cirrhosis is severe scarring and poor function of the liver caused by long-term exposure to toxins such as alcohol or viral infections. Certain medications and disorder can also cause cirrhosis.

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Hypertensive Heart Disease

Hypertensive heart disease refers to heart conditions caused by high blood pressure. Possible signs of acute hypertension include sweating and chills.

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Emphysema is a lung disease that, along with chronic bronchitis, represents a type of chronic obstructive pulmonary disease (COPD). Lack of oxygen may give skin and lips a bluish hue.

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Glomerulonephritis occurs when blood filtering vessels in the kidneys are damaged. This may contribute to kidney failure, which causes fatigue, insomnia, itchy skin, and other symptoms.

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Ischemic Cardiomyopathy

Ischemic cardiomyopathy is a condition that occurs when the heart muscle is weakened due to insufficient blood flow to the heart's muscle. This inhibits the heart's ability to pump blood and can lead to heart failure.

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Chronic Bronchitis

People often develop acute bronchitis after a viral chest infection. Blue-colored lips ankle or foot swelling can result.

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Myocarditis is inflammation of the heart muscle. It is a rare condition that can be caused by any number of autoimmune diseases, viral, bacterial, or fungal infections, or parasites. When you have an infection or a...

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Infective Endocarditis

Infective endocarditis is an infection of the heart, normally caused by bacteria in the blood stream. It is a serious medical condition. If left untreated, the infection can damage your heart and may even cause death.

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Endocarditis is inflammation of the inner lining of the heart. Possible symptoms of this condition include pale skin, chills, and night sweats.

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Mitral Valve Stenosis

Your mitral valve is located on the left side of your heart, between two chambers, the atrium and the ventricle. Blood is pumped from the left atrium through the mitral valve and into the left ventricle on its way t...

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Rheumatic Fever

Rheumatic fever is a possible and potentially serious complication of strep throat. It tends to occur in children between five and 15 years old. Rash is one possible sign of this condition.

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ALS (Lou Gehrig's Disease)

Amyotrophic Lateral Sclerosis (ALS) is not contagious. It is a degenerative disease that affects the brain and spinal cord. A chronic disorder, it causes a loss of control of voluntary muscles. The nerves controllin...

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Acute Nephritis

Think of your kidneys as your body's filters, a sophisticated waste removal system comprised of two bean-shaped organs. Every day, your hard working kidneys process 200 quarts of blood in a day and remove two quarts o...

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Teenage Pregnancy

Teenage pregnancy is pregnancy in a woman 19 years of age or younger. A woman can get pregnant if she has vaginal sex with a man at any age after she has started having regular monthly periods. Some signs of pregnanc...

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.