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What causes general weakness and muscle pain? 44 possible conditions

See a list of possible causes in order from the most common to the least.


CFS (Chronic Fatigue Syndrome)

Chronic fatigue syndrome (CFS) is a debilitating disorder characterized by extreme tiredness that can't be explained by an underlying medical condition.

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Cold and Flu Overview

Common colds and influenza are contagious infections that affect the respiratory system. Both are airborne illnesses, spread through coughing and sneezing. Shared symptoms include headache, cough, sore throat, and more.

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Common Cold Overview

The common cold is a virus that involves symptoms like sneezing, a runny nose and a headache. Learn the causes, symptoms and treatments for the common cold now!

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Malaria is a life-threatening disease. It is typically transmitted through the bite of a mosquito infected with Anopheles. Nausea, chills, fever, and diarrhea are common symptoms.

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Low Blood Sugar (Hypoglycemia)

This condition is considered a medical emergency. Urgent care may be required.

Also known as hypoglycemia, low blood sugar can be a dangerous condition. Hypoglycemia is rare in people who are not suffering from diabetes, the chronic disease that affects the body's ability to regulate blood sugar...

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There are many symptoms of the autoimmune disease HIV/AIDS, including persistent skin rashes, night sweats, and mouth sores.

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What is Fibromyalgia?

Fibromyalgia is a chronic disorder characterized by widespread, unexplained pain in tender points in muscles and joints, including the head, neck, and sides of hips.

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Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease and the most common type of lupus. One of its common symptoms is a rash on the cheeks and nose called a "butterfly rash."

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The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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Rheumatoid Arthritis Overview

Rheumatoid arthritis (RA) is an autoimmune disease, a disease in which the immune system mistakes the body's own cells for invaders. In RA, the immune system attacks the synovia, the membranes lining the joints.

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In hyperparathyroidism, the parathyroid glands make too much of their hormone. It affects a number of body systems and can cause skin changes, including brittle nails and itching.

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Hepatitis refers to an inflammatory condition of the liver. It's commonly caused by a viral infection, but there are other possible causes of hepatitis.

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Ebola Virus and Disease

This condition is considered a medical emergency. Urgent care may be required.

Ebola disease is a rare, often fatal illness. One of its late-stage symptoms is a bleeding rash over the entire body.

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Dengue Fever

Dengue fever is a disease that affects much of the tropical region and is caused by one of four dengue viruses. A skin rash between two and five days after the initial fever is a common symptom.

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Temporal Arteritis

Temporal arteritis is a condition in which the temporal arteries, which supply blood to the head and scalp, become inflamed or damaged. Scalp sensitivity or tenderness is a symptom.

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Polymyalgia Rheumatica

Polymyalgia rheumatica is an inflammatory disorder that causes pain and stiffness in various parts of the body, including the shoulders, neck, arms, thighs, and hips. The cause of this disorder is unknown.

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Rhabdomyolysis is breakdown of muscle fibers. Muscle breakdown causes the release of myoglobin into the bloodstream. Myoglobin can cause kidney damage. Symptoms include dark urine, muscle weakness, and fatigue. Abou...

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Lyme Disease

Lyme disease is an infectious condition transmitted via tick bite. A "bull's eye" rash at the site of the bite is an early symptom of this disease.

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Colorado Tick Fever

An infected Rocky Mountain Wood tick can spread Colorado tick fever, a viral infection. A faint, occasional rash is one symptom of this condition.

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Learn about sarcoidosis and its causes, symptoms, diagnosis, treatment, and potential complications.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.