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What causes general weakness and joint pain? 45 possible conditions

See a list of possible causes in order from the most common to the least.

1

CFS (Chronic Fatigue Syndrome)

Chronic fatigue syndrome (CFS) is a debilitating disorder characterized by extreme tiredness that can't be explained by an underlying medical condition.

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2

Cold and Flu Overview

Common colds and influenza are contagious infections that affect the respiratory system. Both are airborne illnesses, spread through coughing and sneezing. Shared symptoms include headache, cough, sore throat, and more.

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3

AIDS

If left untreated, HIV can lead to AIDS. AIDS weakens your immune system to the point where it can no longer fight off disease and infection. Learn more.

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4

What is Fibromyalgia?

Fibromyalgia is a disorder tied to widespread pain in your muscles and bones, areas of tenderness, and fatigue. Learn about its symptoms, treatment, and more.

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5

Rheumatoid Arthritis Overview

Rheumatoid arthritis is an autoimmune disease. It causes joint problems. In autoimmune diseases, the immune system mistakes the body's own cells for invaders.

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6

Ankylosing Spondylitis

Ankylosing spondylitis is a form of arthritis that primarily affects your spine. It causes severe inflammation of the vertebrae that might eventually lead to chronic pain and disability.

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7

Hypothyroidism

The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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8

Rheumatic Fever

Rheumatic fever is a complication of strep throat. If it's left untreated, it can cause permanent damage to your heart. Find out about symptoms and treatment.

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9

Leukemia

Leukemia is a cancer of the blood cells. Excessive sweating at night, fatigue, weight loss, bone pain, and easy bleeding or bruising are signs of this disease.

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10

Polymyalgia Rheumatica

Polymyalgia rheumatica is an inflammatory disorder that causes muscle pain and stiffness. Learn about its symptoms, diagnosis, and treatment.

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11

Lyme Disease

Lyme disease is an infectious condition transmitted via tick bite. A "bull's eye" rash at the site of the bite is an early symptom of this disease.

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12

Infectious Mononucleosis

Infectious mononucleosis, or mono, refers to a group of symptoms usually caused by the Epstein-Barr virus (EBV).

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13

Systemic Lupus Erythematosus

Systemic lupus erythematosus, the most common form of lupus, is a chronic autoimmune disease that can cause severe fatigue and joint pain. Learn more about it.

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14

Sarcoidosis

Learn about sarcoidosis and its causes, symptoms, diagnosis, treatment, and potential complications.

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15

Ulcerative Colitis

Ulcerative colitis is an inflammatory bowel disease. It occurs when the lining of the large intestine (colon or bowel) and the rectum become inflamed.

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16

Polio

Poliomyelitis, or polio, is a highly contagious disease that is caused by a virus that attacks the body's nervous system.

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17

Fifth Disease

Fifth disease is common in children. It causes a red rash on the arms, legs, and cheeks, and a virus called parvovirus B19 causes it.

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18

Temporal Arteritis

Temporal arteritis occurs when the temporal arteries, which supply blood to the head and brain, become inflamed or damaged.

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19

Lung Cancer Overview

There are two main types of lung cancer: non-small cell and small-cell. Learn about how these lung cancers are caused, your treatment options, and more.

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20

Hepatitis B

Hepatitis B is liver inflammation caused by the hepatitis B virus (HBV).

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.
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