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What causes general weakness and joint pain? 45 possible conditions

See a list of possible causes in order from the most common to the least.


CFS (Chronic Fatigue Syndrome)

Chronic fatigue syndrome (CFS) is a debilitating disorder characterized by intense fatigue that cannot be cured with sleep. Mental and physical activities may cause symptoms to worsen. When fatigue cannot be linked to ...

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Cold and Flu Overview

Common colds and influenza are contagious infections that affect the respiratory system. Both are airborne illnesses, spread through coughing and sneezing. Shared symptoms include headache, cough, sore throat, and more.

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There are many symptoms of the autoimmune disease HIV/AIDS, including persistent skin rashes, night sweats, and mouth sores.

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What is Fibromyalgia?

Fibromyalgia is a chronic disorder characterized by widespread, unexplained pain in tender points in muscles and joints, including the head, neck, and sides of hips.

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Rheumatoid Arthritis Overview

Rheumatoid arthritis (RA) is an autoimmune disease, a disease in which the immune system mistakes the body's own cells for invaders. In RA, the immune system attacks the synovia, the membranes lining the joints.

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Ankylosing Spondylitis

Ankylosing spondylitis is a form of arthritis that primarily affects your spine. It causes severe inflammation of the vertebrae that might eventually lead to chronic pain and disability.

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The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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Rheumatic Fever

Rheumatic fever is a possible and potentially serious complication of strep throat. It tends to occur in children between five and 15 years old. Rash is one possible sign of this condition.

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Leukemia is a cancer of the blood cells. Excessive sweating at night, constant fatigue, weight loss, bone pain, and easy bleeding or bruising are all signs of this disease.

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Polymyalgia Rheumatica

Polymyalgia rheumatica is an inflammatory disorder that causes pain and stiffness in various parts of the body, including the shoulders, neck, arms, thighs, and hips. The cause of this disorder is unknown.

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Lyme Disease

Lyme disease is an infectious condition transmitted via tick bite. A "bull's eye" rash at the site of the bite is an early symptom of this disease.

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Infectious Mononucleosis

Infectious mononucleosis, or "mono," is a group of symptoms caused by the Epstein-Barr virus. One potential symptom is a pink rash that looks like the measles.

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Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease and the most common type of lupus. One of its common symptoms is a rash on the cheeks and nose called a "butterfly rash."

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Sarcoidosis is an inflammatory disease that causes granulomas, which are clumps of immune cells, to form in different organs. A skin rash is one symptom of sarcoidosis of the skin.

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Ulcerative Colitis

In UC, the lining of the large intestine and the rectum become inflamed. This produces tiny sores or ulcers on the lining of the colon, often accompanied by diarrhea and cramping.

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Poliomyelitis, or polio, is a highly contagious disease that is caused by a virus that attacks the body's nervous system. It is most likely to be contracted by children under five years old.

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Fifth Disease

Fifth disease is caused by a virus and mostly affects children. The disease is marked by feeling unwell, often followed by a red rash on the cheeks.

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Temporal Arteritis

Temporal arteritis is a condition in which the temporal arteries, which supply blood to the head and scalp, become inflamed or damaged. Scalp sensitivity or tenderness is a symptom.

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Lung Cancer Overview

Lung cancer is a cancer that originates in the lungs. Lung cancer often goes undetected in the early stages, since symptoms don't usually present themselves until the advanced stages of the disease.

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Hepatitis B

Hepatitis B is liver inflammation caused by the hepatitis B virus (HBV). It can be chronic or acute, but most cases are chronic. This disease is easily spread through blood, saliva, and other body fluids.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.