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What causes gastrointestinal bleeding and unintentional weight loss? 17 possible conditions

See a list of possible causes in order from the most common to the least.


Stomach Ulcer

Stomach ulcers are painful sores in the stomach lining or small intestine. They occur when the mucus that protects the stomach from digestive juices is reduced.

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Cirrhosis is the severe scarring and poor function of the liver caused by long-term exposure to toxins such as alcohol or viral infections.

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Peptic Ulcer

Peptic ulcers are painful sores in the lining of the stomach, esophagus, or small intestine. Peptic ulcers are a fairly common health problem.

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Esophageal Cancer

Esophageal cancer occurs when a malignant (cancerous) tumor forms in the lining of the esophagus, which is the muscular tube responsible for moving food from the throat to the stomach. As the cancer grows, it can affec...

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Crohn’s Disease

Crohn's disease is a chronic bowel disease that causes severe inflammation of the digestive tract. It is associated with abdominal pain, diarrhea, and may affect your quality of life. Crohn's disease is characterized b...

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Liver Cancer

Liver cancer causes destruction of liver cells and interferes with the ability of the liver to function normally. Cancer that originates in the liver can spread from the liver to other parts of the body.

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Stomach Cancer (Gastric Adenocarcinoma)

Stomach cancer occurs when cancerous cells form in the stomach lining. Because it's difficult to detect, it's often not diagnosed until it's more advanced.

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Colorectal (Colon) Cancer

Colorectal cancer is a cancer that originates in the rectum or colon. Both of these organs are located at the lower portion of your digestive system. The colon is at the end of the large intestine and the rectum is a...

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Colitis is inflammation of the colon, often causing discomfort and pain in the abdomen, as well as other gastrointestinal symptoms. Colitis has many possible causes, which determine the type.

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Hookworm Infections

Hookworms are parasites that affect the small intestine and lungs. The first sign of infection is usually a rash where the parasite entered the skin, followed by diarrhea.

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Lactose Intolerance

Lactose intolerence occurs when a person's small intestine can't break down lactose, an enzyme found in dairy foods. The condition can cause many gastrointestinal symptoms.

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Amebiasis is a parasitic infection, common in the tropics and caused by contaminated water. Symptoms can be severe and usually start 1-4 weeks after exposure.

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Anal Cancer

Anal cancer is an uncommon cancer in the anal canal. It's easy to mistake symptoms of anal cancer for other conditions such as hemorrhoids, which could delay a diagnosis. Human papillomavirus is closely related to ana...

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Celiac Disease (Gluten Intolerance)

Celiac disease is a digestive disorder caused by an immune reaction to gluten. Symptoms vary but can include arthritis, fatigue, and abdominal symptoms.

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Medullary Cystic Disease

Medullary cystic kidney disease is a rare condition that causes cysts to form on kidneys. Kidney failure may result, symptoms of which can include changes in skin color and itchy skin.

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Glomerulonephritis is a serious illness that can be life-threatening and requires immediate treatment. The condition is sometimes called nephritis.

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Polymyalgia Rheumatica

Polymyalgia rheumatica is an inflammatory disorder that causes pain and stiffness in various parts of the body, including the shoulders, neck, arms, thighs, and hips. The cause of this disorder is unknown.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.