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What causes fever, headache and unintentional weight loss? 11 possible conditions

See a list of possible causes in order from the most common to the least.



Tuberculosis (TB) is a highly infectious disease that primarily affects the lungs. A severe and long-lasting cough, fever, and night sweats could indicate an active TB infection.

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Acute HIV Infection

Acute HIV infection is the primary stage of infection by the human immunodeficiency virus. There are several telltale symptoms, one of which is a rash.

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There are many symptoms of the autoimmune disease HIV/AIDS, including persistent skin rashes, night sweats, and mouth sores.

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Temporal Arteritis

Temporal arteritis is a condition in which the temporal arteries, which supply blood to the head and scalp, become inflamed or damaged. Scalp sensitivity or tenderness is a symptom.

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Leukemia is a cancer of the blood cells. Excessive sweating at night, fatigue, weight loss, bone pain, and easy bleeding or bruising are signs of this disease.

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Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease and the most common type of lupus. One of its common symptoms is a rash on the cheeks and nose called a "butterfly rash."

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Glomerulonephritis is a serious illness that can be life-threatening and requires immediate treatment. The condition is sometimes called nephritis.

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Brucellosis is a rare disease usually spread through ingesting infected raw meat and unpasteurized milk. Back pain, lethargy, chills, and fever may occur and could lead to complications.

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Valley Fever (Coccidioidomycosis)

Coccidioidomycosis, also known as valley fever, is a fungal infection that starts in the lungs and can potentially spread to the rest of the body. Fever, chills and sweating are common.

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Aspergillosis is an infection, allergic reaction, or fungal growth caused by the Aspergillus fungus. The fungus usually grows on decaying vegetation and dead leaves. Being exposed to the fungus does not necessarily mea...

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Addisonian Crisis (Acute Adrenal Crisis)

This condition is considered a medical emergency. Urgent care may be required.

People with Addison's disease don't make enough cortisol or aldosterone. Addisonian crisis is a potentially life-threatening condition indicated by nausea, abdominal pain, fever, and chills.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.