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What causes fatigue and weight loss? 66 possible conditions

See a list of possible causes in order from the most common to the least.


Anorexia Nervosa

Anorexia is an eating disorder in which obsessive worry about body weight and the food you eat can result in severe weight loss. Symptoms include constipation, missed period, and thinning hair.

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There are many symptoms of the autoimmune disease HIV/AIDS, including persistent skin rashes, night sweats, and mouth sores.

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What is anxiety? Anxiety often manifests itself as an apprehension about daily life. Learn the basics with this overview of the types of anxiety disorders.

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Diabetes Overview

Diabetes is a group of chronic metabolic diseases caused by defects in insulin production or function. Advanced diabetes may cause stomach pain, nausea, dizziness, and cramps.

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Tuberculosis (TB) is a highly infectious disease that primarily affects the lungs. A severe and long-lasting cough, fever, and night sweats could indicate an active TB infection.

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Hepatitis refers to an inflammatory condition of the liver. It's commonly caused by a viral infection, but there are other possible causes of hepatitis.

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Heart Failure

Right-side heart failure occurs when the right ventricle can't properly pump blood to your lungs to collect oxygen. Excessive fatigue, shortness of breath and abdominal bloating are signs.

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The thyroid gland produces a hormone that controls how your cells use energy. Hyperthyroidism occurs when the body produces excessive amounts.

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Peptic Ulcer

Peptic ulcers are painful sores in the lining of the stomach, esophagus, or small intestine. Peptic ulcers are a fairly common health problem.

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Cirrhosis is the severe scarring and poor function of the liver caused by long-term exposure to toxins such as alcohol or viral infections.

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Bipolar Disorder

Bipolar disorder mental illness marked by extreme from mania to depression. Bipolar disorder is also called bipolar disease or manic depression.

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Type 1 Diabetes

Type 1 diabetes is a chronic disease that result high levels of glucose in the blood due to a lack of insulin production. Glucose is a natural sugar that your body uses as a source of energy.

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Underactive Pituitary Gland (Hypopituitarism)

The pituitary gland releases hormones that play roles in body processes like bone growth and metabolism. An underactive pituitary can disrupt these processes. Causes may include tumors, traumatic injuries, and diseases.

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Hodgkin's Disease

Hodgkin's disease is a type of lymphoma, a blood cancer that starts in the lymphatic system. It can occur at any age, but is most prevalent between the ages of 15 and 40 and after the age of 55.

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Leukemia is a cancer of the blood cells. Excessive sweating at night, fatigue, weight loss, bone pain, and easy bleeding or bruising are signs of this disease.

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Hookworm Infections

Hookworms are parasites that affect the small intestine and lungs. The first sign of infection is usually a rash where the parasite entered the skin, followed by diarrhea.

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Lactose Intolerance

Lactose intolerence occurs when a person's small intestine can't break down lactose, an enzyme found in dairy foods. The condition can cause many gastrointestinal symptoms.

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Emphysema is a lung disease that, along with chronic bronchitis, represents a type of chronic obstructive pulmonary disease (COPD). Lack of oxygen may give skin and lips a bluish hue.

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Celiac Disease (Gluten Intolerance)

Celiac disease is a digestive disorder caused by an immune reaction to gluten. Symptoms vary but can include arthritis, fatigue, and abdominal symptoms.

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Postpartum Depression

Postpartum depression affects as many as 13 percent of new mothers. In the U.S., that's half a million women. Learn about symptoms, causes, risks, and more.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.