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What causes fatigue and numbness of limbs? 11 possible conditions

See a list of possible causes in order from the most common to the least.



Radiculopathy refers to disease of the spinal nerve roots. Radiculopathy produces pain , numbness, or weakness radiating from the spine.

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Peripheral Neuropathy

Peripheral neuropathy occurs when nerves malfunction because they're damaged or destroyed. You'll notice a tingling, numbness, or weakness, and possibly sweating, constipation, or diarrhea.

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Diabetic Neuropathy

Diabetic neuropathy is a common complication of types 1 and 2 diabetes due to uncontrolled high blood sugar levels that result in damage to the nerves. According to the American Diabetes Association (ADA), between 6...

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Necrotizing Vasculitis

This condition is considered a medical emergency. Urgent care may be required.

Necrotizing vasculitis is the inflammation of blood vessel walls. It can interrupt blood flow, causing skin, muscle, and blood vessel damage, and death of tissues and organs. Its symptoms can affect the entire body.

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Whiplash occurs when a person's head moves backward and then forward very suddenly with great force. This injury is most common following a car collision.

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Migraine with Aura

Migraine is a disorder characterized by repeated attacks of severe headache. Symptoms include throbbing or pulsating pain, usually on only one side of the head, and can last between four hours and three days.

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Multiple Sclerosis Overview

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. MS can cause varying symptoms that appear with a wide range of severity, from mild discomfort to complete disability.

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Megaloblastic Anemia

Megaloblastic anemia is a blood disorder marked by the appearance of very large red blood cells that crowd out healthy cells, causing anemia.

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Pernicious Anemia

Pernicious anemia (PA) is an autoimmune disorder in which the body fails to make enough healthy red blood cells (RBCs), resulting in vitamin B-12 deficiency. Most people experience a burning or sore tongue.

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Mononeuropathy is a pathological effect of a single large nerve. It can be caused by injury, nutritional deficiency, or autoimmune condition. Common symptoms are numbness, tingling, or burning.

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Malignant Hypertension (Arteriolar Nephrosclerosis)

This form of high blood pressure comes on very quickly and requires immediate medical help. You're especially at risk if you already have hypertension or smoke.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.