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What causes fatigue and muscle cramp? 10 possible conditions

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See a list of possible causes in order from the most common to the least.


Low Blood Potassium

Hypokalemia occurs when the blood's potassium levels are too low. A normal level of potassium is 3.6-5.2 millimoles per liter. Levels below 3.6 are considered low.

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Low Blood Sodium (Hyponatremia)

Low blood sodium, or hyponatremia, occurs when water and sodium are out of balance in your body. A quick drop in sodium levels can cause weakness, headache, nausea, and muscle cramps.

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Peripheral Neuropathy

Peripheral neuropathy occurs when nerves malfunction because they're damaged or destroyed. You'll notice a tingling, numbness, or weakness, and possibly sweating, constipation, or diarrhea.

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Heat Emergencies

This condition is considered a medical emergency. Urgent care may be required.

Heat emergencies are health crises caused by exposure to hot weather and sun. Heat emergencies have three stages: heat cramps, heat exhaustion, and heatstroke. All three stages are serious.

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Diabetic Ketoacidosis

This condition is considered a medical emergency. Urgent care may be required.

Diabetic ketoacidosis (DKA) is a serious complication that stems from diabetes. If you don't have enough insulin to help your body process sugars (glucose), your body will start burning fat to fuel itself. As a result...

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Glomerulonephritis is a serious illness that can be life-threatening and requires immediate treatment. The condition is sometimes called nephritis.

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Marine Animal Bites or Stings

This condition is considered a medical emergency. Urgent care may be required.

Stingrays have venomous spines on their tails that can cause a painful wound, nausea, and weakness, and sometimes death. Swimming or snorkeling in shallow waters puts you at risk for coming in contact.

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Chronic Kidney Disease

Chronic kidney disease (CKD) is the progressive and irreversible destruction of the kidneys. The most common causes of CKD are high blood pressure and diabetes.

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Celiac Disease (Gluten Intolerance)

Celiac disease is a digestive disorder caused by an immune reaction to gluten. Symptoms vary but can include arthritis, fatigue, and abdominal symptoms.

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Medullary Cystic Disease

Medullary cystic kidney disease is a rare condition that causes cysts to form on kidneys. Kidney failure may result, symptoms of which can include changes in skin color and itchy skin.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.