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What causes fatigue, loss of appetite and weight gain? 14 possible conditions

See a list of possible causes in order from the most common to the least.



The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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Bleeding or spotting, increased need to urinate, tender breasts, fatigue, nausea, and missed period are signs of pregnancy.

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There are many symptoms of the autoimmune disease HIV/AIDS, including persistent skin rashes, night sweats, and mouth sores.

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Bipolar Disorder

Bipolar disorder mental illness marked by extreme from mania to depression. Bipolar disorder is also called bipolar disease or manic depression.

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Congestive Heart Failure (CHF)

Congestive heart failure (CHF) is a chronic condition that affects the chambers of your heart. CHF refers to fluid buildup around your heart.

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PMS (Premenstrual Syndrome)

PMS symptoms start five to 11 days before menstruation and typically go away once menstruation begins. The cause of PMS is unknown.

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Dysthymia is chronic depression with recurring symptoms of sadness and hopelessness lasting for several years. It is not characterized by acute depressive episodes but by an ongoing depressed feeling. Dysthymia is mos...

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Postpartum Depression

Postpartum depression affects as many as 13 percent of new mothers. In the U.S., that's half a million women. Learn about symptoms, causes, risks, and more.

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Alcoholic Liver Disease

Damage to the liver from excessive drinking can lead to ALD. Years of alcohol abuse cause the liver to become inflamed and swollen. This damage can also cause scarring known as cirrhosis. Cirrhosis is the final stage o...

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Teenage Pregnancy

Teenage pregnancy is pregnancy in a woman 19 years of age or younger. A woman can get pregnant if she has vaginal sex with a man at any age after she has started having regular monthly periods. Some signs of pregnanc...

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Gestational Diabetes

During pregnancy, some women develop high levels of blood sugar, a condition known as gestational diabetes, around the 24th week of pregnancy. In most cases, the condition develops in women who never had diabetes.

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Pituitary Cancer

The pituitary gland is a very small gland of major importance to the functioning of the human body. It is located directly behind the eyes and below the front of the brain. It is about the size of a pea. Despite it...

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Diabetic Nephropathy

Diabetic nephropathy is a type of progressive kidney disease that occurs in people who have type 1 or type 2 diabetes. The University of Washington estimates that 20 to 40 percent of people with diabetes will ge...

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Ovarian Cancer

The ovaries are small, almond-shaped organs located on either side of the uterus that produce eggs. As the disease progresses, symptoms include back pain and indigestion.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.