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What causes fatigue, loss of appetite and rash? 13 possible conditions

See a list of possible causes in order from the most common to the least.


Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease and the most common type of lupus. One of its common symptoms is a rash on the cheeks and nose called a "butterfly rash."

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Infectious Mononucleosis

Infectious mononucleosis, or "mono," is a group of symptoms caused by the Epstein-Barr virus. One potential symptom is a pink rash that looks like the measles.

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Cellulitis is a common, often painful skin infection that first appears as a red, swollen area that feels hot and tender to the touch. If left untreated, it can become life-threatening.

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Hookworm Infections

Hookworms are parasites that affect the small intestine and lungs. The first sign of infection is usually a rash where the parasite entered the skin, followed by diarrhea.

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Chemical Burns

This condition is considered a medical emergency. Urgent care may be required.

Chemical burns occur when the skin or eyes come into contact with irritants, such as acids or bases. Symptoms vary, but skin reactions, pain or numbness are common.

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Leukemia is a cancer of the blood cells. Excessive sweating at night, constant fatigue, weight loss, bone pain, and easy bleeding or bruising are all signs of this disease.

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Addisonian Crisis (Acute Adrenal Crisis)

This condition is considered a medical emergency. Urgent care may be required.

People with Addison's disease don't make enough cortisol or aldosterone. Addisonian crisis is a potentially life-threatening condition indicated by nausea, abdominal pain, fever, and chills.

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Acute HIV Infection

Acute HIV infection is the primary stage of infection by the human immunodeficiency virus. There are several telltale symptoms, one of which is a rash.

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Erysipelas is a bacterial infection in the upper layer of your skin. A raised rash or blisters occur most commonly on the legs and face, and may be accompanied by fever and chills.

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West Nile Virus Infection (West Nile Fever)

Spread by mosquitos, West Nile virus symptoms can vary in severity. Diarrhea and abdominal pain usually appears within two weeks of infection.

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Sarcoidosis is an inflammatory disease that causes granulomas, which are clumps of immune cells, to form in different organs. A skin rash is one symptom of sarcoidosis of the skin.

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Colorado Tick Fever

An infected Rocky Mountain Wood tick can spread Colorado tick fever, a viral infection. A faint, occasional rash is one symptom of this condition.

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MRSA (Staph) Infection

MRSA (methicillin-resistant Staphylococcus) is a type of contagious bacterial infection that is resistant to beta-lactam antibiotics. CA-MRSA typically causes lesions that are red, swollen, and painful to touch.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.