Fatigue, Joint pain: 51 Possible Causes
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What causes fatigue and joint pain? 51 possible conditions

See a list of possible causes in order from the most common to the least.


CFS (Chronic Fatigue Syndrome)

Chronic fatigue syndrome (CFS) is a debilitating disorder characterized by extreme tiredness that can't be explained by an underlying medical condition.

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What is Fibromyalgia?

Fibromyalgia is a chronic disorder characterized by widespread, unexplained pain in tender points in muscles and joints, including the head, neck, and sides of hips.

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Cold and Flu Overview

Common colds and influenza are contagious infections that affect the respiratory system. Both are airborne illnesses, spread through coughing and sneezing. Shared symptoms include headache, cough, sore throat, and more.

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Rheumatoid Arthritis Overview

Rheumatoid arthritis is an autoimmune disease. It causes joint problems. In autoimmune diseases, the immune system mistakes the body's own cells for invaders.

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Ankylosing Spondylitis

Ankylosing spondylitis is a form of arthritis that primarily affects your spine. It causes severe inflammation of the vertebrae that might eventually lead to chronic pain and disability.

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Rheumatic Fever

Rheumatic fever is a complication of strep throat. If it's left untreated, it can cause permanent damage to your heart. Find out about symptoms and treatment.

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There are many symptoms of HIV/AIDS, including persistent skin rashes, night sweats, and mouth sores.

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Systemic Lupus Erythematosus

Systemic lupus erythematosus, the most common form of lupus, is a chronic autoimmune disease that can cause severe fatigue and joint pain. Learn more about it.

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The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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Polymyalgia Rheumatica

Polymyalgia rheumatica is an inflammatory disorder that causes muscle pain and stiffness. Learn about its symptoms, diagnosis, and treatment.

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Lyme Disease

Lyme disease is an infectious condition transmitted via tick bite. A "bull's eye" rash at the site of the bite is an early symptom of this disease.

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Learn about sarcoidosis and its causes, symptoms, diagnosis, treatment, and potential complications.

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Infectious Mononucleosis

Infectious mononucleosis, or mono, refers to a group of symptoms usually caused by the Epstein-Barr virus (EBV).

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Ulcerative Colitis

Ulcerative colitis is an inflammatory bowel disease. It occurs when the lining of the large intestine (colon or bowel) and the rectum become inflamed.

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Poliomyelitis, or polio, is a highly contagious disease that is caused by a virus that attacks the body's nervous system.

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Fifth Disease

Fifth disease is common in children. It causes a red rash on the arms, legs, and cheeks, and a virus called parvovirus B19 causes it.

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Temporal Arteritis

Temporal arteritis occurs when the temporal arteries, which supply blood to the head and brain, become inflamed or damaged.

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Leukemia is a cancer of the blood cells. There are several types of blood cells, including red blood cells (RBCs), white blood cells (WBCs), and platelets. Generally, leukemia refers to cancers of the WBCs. Two types o...

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Hepatitis refers to an inflammatory condition of the liver. It's commonly caused by a viral infection, but there are other possible causes of hepatitis.

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Sickle Cell Anemia

Red blood cells are normally shaped like discs, which allows them to travel through blood vessels. Sickle cell disease causes sickle cells to be sickle-shaped.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.