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What causes fatigue and irritable mood? 31 possible conditions

See a list of possible causes in order from the most common to the least.

1

CFS (Chronic Fatigue Syndrome)

Chronic fatigue syndrome (CFS) is a debilitating disorder characterized by extreme tiredness that can't be explained by an underlying medical condition.

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2

AIDS

If left untreated, HIV can lead to AIDS. AIDS weakens your immune system to the point where it can no longer fight off disease and infection. Learn more.

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3

Low Blood Sugar (Hypoglycemia)

This condition is considered a medical emergency. Urgent care may be required.

Hypoglycemia, or low blood sugar, is a potentially dangerous condition that's most common in people with diabetes. Learn what causes it and how to prevent it.

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4

Bipolar Disorder

Bipolar disorder is a mental illness marked by extreme shifts in mood ranging from mania to depression. It is also called bipolar disease or manic depression.

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5

Low Blood Sodium (Hyponatremia)

Low blood sodium, or hyponatremia, occurs when water and sodium are out of balance in your body. A quick drop in sodium levels can cause weakness, headache, nausea, and muscle cramps.

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6

Sleeplessness

Insomnia is a sleep disorder. Individuals who suffer from insomnia find it difficult to fall asleep, stay asleep, or both. They don't feel refreshed when they wake up from sleeping. This can lead to fatigue and othe...

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7

Anxiety

Learn more about anxiety with this overview of anxiety disorders.

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8

Iron Deficiency Anemia

Iron-deficiency anemia is the most common type of anemia, which occurs when the body does not have enough of the mineral iron. The body needs iron to produce hemoglobin.

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9

Sinus Infections (Sinusitis)

A sinus infection, or sinusitis, is a common condition that affects 30 million people in the United States each year, according to the National Institute of Allergy and Infectious Diseases. The infection occurs whe...

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10

Diabetes Overview

Diabetes is a group of chronic metabolic diseases caused by defects in insulin production or function. Advanced diabetes may cause stomach pain, nausea, dizziness, and cramps.

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11

PMS (Premenstrual Syndrome)

Premenstrual syndrome causes a wide variety of emotional and physical symptoms. Learn more about it.

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12

Meningococcemia

This condition is considered a medical emergency. Urgent care may be required.

Meningococcemia is a bacterial infection that can lead to meningitis. Learn more about the symptoms.

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13

Generalized Anxiety Disorder

People who suffer from generalized anxiety disorder, or GAD, worry uncontrollably about common occurrences and situations. The condition may also be called chronic anxiety neurosis.GAD is different than normal feeling...

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14

Tension Headaches

A tension headache is the most common type of headache. It can cause mild, moderate, or intense pain in your head, neck, and behind your eyes.

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15

Concussion

This condition is considered a medical emergency. Urgent care may be required.

Concussions can cause serious symptoms that require medical treatment. A concussion is a traumatic brain injury that results in an altered mental state.

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16

Cocaine and related disorders

According to the National Institute on Drug Abuse, about 15 percent of people in the U.S. have tried cocaine. Find out more about the effects of addiction.

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17

Graves' Disease

Graves' disease is an autoimmune disorder that causes your thyroid gland to create too much thyroid hormone. Learn the symptoms and your treatment options.

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18

Whiplash

Whiplash occurs when a person's head moves backward and then forward very suddenly with great force. This injury is most common following a car collision.

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19

Migraine with Aura

Migraine is a disorder characterized by repeated attacks of severe headache. Symptoms include throbbing or pulsating pain, usually on only one side of the head, and can last between four hours and three days.

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20

Alcohol Withdrawal Syndrome

This condition is considered a medical emergency. Urgent care may be required.

Alcohol withdrawal syndrome (AWS) is the name for the symptoms that occur when a heavy drinker suddenly stops or significantly reduces their alcohol intake. With AWS, you may feel mild anxiety and fatigue. You may als...

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.
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