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What causes fatigue, general weakness and weight gain? 17 possible conditions

See a list of possible causes in order from the most common to the least.



Obesity is defined as having a body mass index (BMI) of 30 or more. BMI is calculated using a person's weight and height. It can lead to other conditions like diabetes, heart disease, and cancer.

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The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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There are many symptoms of the autoimmune disease HIV/AIDS, including persistent skin rashes, night sweats, and mouth sores.

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Bleeding or spotting, increased need to urinate, tender breasts, fatigue, nausea, and missed period are signs of pregnancy.

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Congestive Heart Failure (CHF)

Congestive heart failure is a chronic condition that affects the four chambers of the heart. Early symptoms include fatigue and weight gain. Irregular heart beat and wheezing indicate a worsening.

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Bipolar Disorder

Bipolar disorder mental illness marked by extreme from mania to depression. Bipolar disorder is also called bipolar disease or manic depression.

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Primary Hypothyroidism

Your thyroid gland controls the metabolism of all your cells. Your pituitary gland releases a hormone known as TSH (thyroid stimulating hormone) to stimulate your thyroid. Your thyroid then releases two hormones, T3 an...

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Seasonal Affective Disorder

Seasonal affective disorder (SAD) is a form of depression. People affected by SAD display symptoms of depression at the same time every year, typically during the fall and winter months. According to the America...

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Postpartum Depression

Postpartum depression affects as many as 13 percent of new mothers. In the U.S., that's half a million women. Learn about symptoms, causes, risks, and more.

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Teenage Pregnancy

Teenage pregnancy is pregnancy in a woman 19 years of age or younger. A woman can get pregnant if she has vaginal sex with a man at any age after she has started having regular monthly periods. Some signs of pregnanc...

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Gestational Diabetes

During pregnancy, some women develop high levels of blood sugar, a condition known as gestational diabetes, around the 24th week of pregnancy. In most cases, the condition develops in women who never had diabetes.

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PMS (Premenstrual Syndrome)

PMS symptoms start five to 11 days before menstruation and typically go away once menstruation begins. The cause of PMS is unknown.

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Hashimoto's Disease

Hashimoto's disease is a condition that damages the thyroid's ability to function properly. It can cause a goiter, or enlarged thyroid, which can make the front of the neck look swollen.

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Cushing Syndrome

Cushing syndrome is when your body has abnormally high levels of a hormone called cortisol. This can occur due to overuse of corticosteroid medication, malnutrition, alcoholism, or other factors.

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Alcoholic Liver Disease

Damage to the liver from excessive drinking can lead to ALD. Years of alcohol abuse cause the liver to become inflamed and swollen. This damage can also cause scarring known as cirrhosis. Cirrhosis is the final stage o...

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Pituitary Cancer

The pituitary gland is a very small gland of major importance to the functioning of the human body. It is located directly behind the eyes and below the front of the brain. It is about the size of a pea. Despite it...

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Diabetic Nephropathy

Diabetic nephropathy is a type of progressive kidney disease that occurs in people who have type 1 or type 2 diabetes. The University of Washington estimates that 20 to 40 percent of people with diabetes will ge...

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.