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What causes fatigue, general weakness and swollen ankle? 17 possible conditions

See a list of possible causes in order from the most common to the least.



Obesity is defined as having a body mass index (BMI) of 30 or more. BMI is calculated using a person's weight and height. It can lead to other conditions like diabetes, heart disease, and cancer.

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Congestive Heart Failure (CHF)

Congestive heart failure (CHF) is a chronic condition that affects the chambers of your heart. CHF refers to fluid buildup around your heart.

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The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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Bleeding or spotting, increased need to urinate, tender breasts, fatigue, nausea, and missed period are signs of pregnancy.

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Emphysema is a lung disease that, along with chronic bronchitis, represents a type of chronic obstructive pulmonary disease (COPD). Lack of oxygen may give skin and lips a bluish hue.

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PMS (Premenstrual Syndrome)

PMS symptoms start five to 11 days before menstruation and typically go away once menstruation begins. The cause of PMS is unknown.

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Cirrhosis is the severe scarring and poor function of the liver caused by long-term exposure to toxins such as alcohol or viral infections.

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Hypertensive Heart Disease

Hypertensive heart disease refers to heart conditions caused by high blood pressure. Possible signs of acute hypertension include sweating and chills.

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Glomerulonephritis is a serious illness that can be life-threatening and requires immediate treatment. The condition is sometimes called nephritis.

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Ischemic Cardiomyopathy

Ischemic cardiomyopathy is a condition that occurs when the heart muscle is weakened due to insufficient blood flow to the heart's muscle. This inhibits the heart's ability to pump blood and can lead to heart failure.

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Chronic Bronchitis

People often develop acute bronchitis after a viral chest infection. Blue-colored lips ankle or foot swelling can result.

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Myocarditis is inflammation of the heart muscle. It is a rare condition that can be caused by any number of autoimmune diseases, viral, bacterial, or fungal infections, or parasites. When you have an infection or a...

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Infective Endocarditis

Infective endocarditis is an infection of the heart, normally caused by bacteria in the blood stream. It is a serious medical condition. If left untreated, the infection can damage your heart and may even cause death.

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Endocarditis is inflammation of the inner lining of the heart. Possible symptoms of this condition include pale skin, chills, and night sweats.

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Mitral Valve Stenosis

Mitral valve stenosis, also known as mitral stenosis, is when the mitral valve opening is narrowed. This means that not enough blood can flow through it.

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Rheumatic Fever

Rheumatic fever is a possible and potentially serious complication of strep throat. It tends to occur in children between five and 15 years old. Rash is one possible sign of this condition.

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Teenage Pregnancy

Teenage pregnancy is pregnancy in a woman 19 years of age or younger. A woman can get pregnant if she has vaginal sex with a man at any age after she has started having regular monthly periods. Some signs of pregnanc...

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.