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What causes fatigue, general weakness and loss of appetite? 77 possible conditions

See a list of possible causes in order from the most common to the least.


Cold and Flu Overview

Common colds and influenza are contagious infections that affect the respiratory system. Both are airborne illnesses, spread through coughing and sneezing. Shared symptoms include headache, cough, sore throat, and more.

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Common Cold Overview

The common cold is a virus that involves symptoms like sneezing, a runny nose and a headache. Learn the causes, symptoms and treatments for the common cold now!

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There are many symptoms of the autoimmune disease HIV/AIDS, including persistent skin rashes, night sweats, and mouth sores.

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The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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Bleeding or spotting, increased need to urinate, tender breasts, fatigue, nausea, and missed period are signs of pregnancy.

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Low Blood Sodium (Hyponatremia)

Low blood sodium, or hyponatremia, occurs when water and sodium are out of balance in your body. A quick drop in sodium levels can cause weakness, headache, nausea, and muscle cramps.

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Congestive Heart Failure (CHF)

Congestive heart failure (CHF) is a chronic condition that affects the chambers of your heart. CHF refers to fluid buildup around your heart.

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PMS (Premenstrual Syndrome)

PMS symptoms start five to 11 days before menstruation and typically go away once menstruation begins. The cause of PMS is unknown.

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Hepatitis refers to an inflammatory condition of the liver. It's commonly caused by a viral infection, but there are other possible causes of hepatitis.

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Bipolar Disorder

Bipolar disorder mental illness marked by extreme from mania to depression. Bipolar disorder is also called bipolar disease or manic depression.

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Heat Emergencies

This condition is considered a medical emergency. Urgent care may be required.

Heat emergencies are health crises caused by exposure to hot weather and sun. Heat emergencies have three stages: heat cramps, heat exhaustion, and heatstroke. All three stages are serious.

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Leukemia is a cancer of the blood cells. Excessive sweating at night, fatigue, weight loss, bone pain, and easy bleeding or bruising are signs of this disease.

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Iron Deficiency Anemia

Iron-deficiency anemia is the most common type of anemia, which occurs when the body does not have enough of the mineral iron. The body needs iron to produce hemoglobin.

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Alcoholic Liver Disease

Damage to the liver from excessive drinking can lead to ALD. Years of alcohol abuse cause the liver to become inflamed and swollen. This damage can also cause scarring known as cirrhosis. Cirrhosis is the final stage o...

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Hypercalcemia is a condition in which you have too much calcium in your blood. Serious cases could cause symptoms like abdominal pain, nausea, constipation, and weakness.

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Infectious Mononucleosis

Infectious mononucleosis, or "mono," is a group of symptoms caused by the Epstein-Barr virus. One potential symptom is a pink rash that looks like the measles.

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Postpartum Depression

Postpartum depression affects as many as 13 percent of new mothers. In the U.S., that's half a million women. Learn about symptoms, causes, risks, and more.

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Celiac Disease (Gluten Intolerance)

Celiac disease is a digestive disorder caused by an immune reaction to gluten. Symptoms vary but can include arthritis, fatigue, and abdominal symptoms.

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Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease and the most common type of lupus. One of its common symptoms is a rash on the cheeks and nose called a "butterfly rash."

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Pneumonia is an infection of the lungs caused by fungi, bacteria, or viruses. General symptoms include chest pain, fever, cough, and difficulty breathing.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.