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What causes diarrhea and general weakness? 35 possible conditions

See a list of possible causes in order from the most common to the least.


Food Poisoning

This condition is considered a medical emergency. Urgent care may be required.

Food poisoning occurs when you consume foods contaminated with bacteria, viruses, or parasites. Symptoms are usually uncomfortable but not severe. Serious reactions can be life threatening and require medical treatment.

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Lactose Intolerance

Lactose intolerence occurs when a person's small intestine can't break down lactose, an enzyme found in dairy foods. The condition can cause many gastrointestinal symptoms.

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Ulcerative Colitis

In UC, the lining of the large intestine and the rectum become inflamed. This produces tiny sores or ulcers on the lining of the colon, often accompanied by diarrhea and cramping.

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Celiac Disease (Gluten Intolerance)

Celiac disease is a digestive disorder caused by an immune reaction to gluten. Symptoms vary but can include arthritis, fatigue, and abdominal symptoms.

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Crohn’s Disease

Crohn's disease is a chronic bowel disease that causes severe inflammation of the digestive tract. It is associated with abdominal pain, diarrhea, and may affect your quality of life. Crohn's disease is characterized b...

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PMS (Premenstrual Syndrome)

PMS symptoms start five to 11 days before menstruation and typically go away once menstruation begins. The cause of PMS is unknown.

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Colorectal (Colon) Cancer

Colorectal cancer is a cancer that originates in the rectum or colon. Both of these organs are located at the lower portion of your digestive system. The colon is at the end of the large intestine and the rectum is a...

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Amebiasis is a parasitic infection, common in tropical countries and caused by contaminated water. Symptoms can be severe and usually start one to four weeks after exposure.

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Diabetic Neuropathy

Diabetic neuropathy is a common complication of types 1 and 2 diabetes due to uncontrolled high blood sugar levels that result in damage to the nerves. According to the American Diabetes Association (ADA), between 6...

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There are many symptoms of the autoimmune disease HIV/AIDS, including persistent skin rashes, night sweats, and mouth sores.

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Colitis is inflammation of the colon, often causing discomfort and pain in the abdomen, as well as other gastrointestinal symptoms. Colitis has many possible causes, which determine the type.

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Caffeine Overdose

You're at risk for caffeine overdose when you ingest more than 200 to 300 mg of caffeine (about three 8-oz cups of coffee) in a day. Dizziness, diarrhea, headache, and severe thirst may occur.

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Cystic Fibrosis

Cystic fibrosis is a recessive genetic disorder that affects cells that produce mucous, sweat, and digestive juices. It may cause severe problems in the lungs, pancreas, liver, and intestine

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E. coli Infection

E. coli is a type of bacteria normally found in intestines. But certain kinds of E. coli can cause infection and severe symptoms like diarrhea and dehydration.

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Peripheral Neuropathy

Peripheral neuropathy occurs when nerves malfunction because they're damaged or destroyed. You'll notice a tingling, numbness, or weakness, and possibly sweating, constipation, or diarrhea.

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The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hyperthyroidism occurs when the body produces excessive amounts, causing rapid heart rates, weight loss, and heat intolerance.

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Megaloblastic Anemia

Megaloblastic anemia is a blood disorder marked by the appearance of very large red blood cells that crowd out healthy cells, causing anemia. Numbness or tingling in hands and feet is common sign.

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Neuroblastoma is a rare cancer that develops in tissues of the sympathetic nervous system (the system that carries brain signals to the body). Early symptoms of the cancer can include fever, diarrhea, and others.

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Legionnaires' Disease

Legionnaires' disease is a serious type of lung infection, or pneumonia, caused by bacteria. Fever, chills, cough, and head and muscle aches are common symptoms.

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Ebola Virus and Disease

This condition is considered a medical emergency. Urgent care may be required.

Ebola disease is a rare, often fatal illness. One of its late-stage symptoms is a bleeding rash over the entire body.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.