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What causes depression and irritable mood? 18 possible conditions

See a list of possible causes in order from the most common to the least.



Menopause is a natural biological process in women that marks the permanent end of menstruation and fertility. Hot flashes, vaginal dryness or pain, and frequent urination are signs.

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PMS (Premenstrual Syndrome)

PMS symptoms start five to 11 days before menstruation and typically go away once menstruation begins. The cause of PMS is unknown.

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Personality Disorder

Everyone has problems getting along with other people some of the time. Personality disorder is a term for several behavior patterns that make it consistently difficult for people to get along with others, regardless o...

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Schizoaffective Disorder

Schizoaffective disorder is a psychological condition that comprises both psychosis (loss of contact with reality) and mood disorders (such as mania or depression). It is divided into two subtypes based on the type o...

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Acute Stress Disorder

In the weeks after a traumatic event, you may develop an anxiety disorder called acute stress disorder (ASD). ASD typically occurs within one month of a traumatic event. It lasts at least two days and up to one month...

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Bipolar Disorder

Bipolar disorder mental illness marked by extreme from mania to depression. Bipolar disorder is also called bipolar disease or manic depression.

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Dementia Overview

Dementia may affect memory, thinking, language, judgment, and behavior. Mental impairment must affect at least two brain functions to be considered dementia.

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This condition is considered a medical emergency. Urgent care may be required.

A concussion is a mild traumatic brain injury. Usually it occurs after an impact to your head or after a whiplash-type injury. A concussion can cause many severe symptoms that affect brain function.

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Alcohol Withdrawal Syndrome

This condition is considered a medical emergency. Urgent care may be required.

Alcohol withdrawal syndrome (AWS) is the name for the symptoms that occur when a heavy drinker suddenly stops or significantly reduces their alcohol intake. With AWS, you may feel mild anxiety and fatigue. You may als...

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Nicotine Dependence

Nicotine addiction occurs when a person becomes addicted to nicotine, which is a chemical found in tobacco. The addiction is physical, mental, and behavioral.

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This condition is considered a medical emergency. Urgent care may be required.

Delirium is an abrupt change in the brain that causes mental confusion and emotional disruption. It makes it difficult to think, remember, sleep, pay attention, and more. You might experience the condition durin...

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Post Traumatic Stress Disorder (PTSD)

Post-traumatic stress disorder (PTSD) is an anxiety disorder that occurs after experiencing or witnessing a traumatic event. PTSD can cause disruptive symptoms of panic, increased arousal, and mental/emotional problems.

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Whiplash occurs when a person's head moves backward and then forward very suddenly with great force. This injury is most common following a car collision.

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Postpartum Depression

Postpartum depression affects as many as 13 percent of new mothers. In the U.S., that's half a million women. Learn about symptoms, causes, risks, and more.

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Alcohol Withdrawal Delirium

This condition is considered a medical emergency. Urgent care may be required.

Alcohol withdrawal delirium (AWD) is the most serious form of alcohol withdrawal. It causes sudden and severe problems in your brain and nervous system. Approximately five percent of hospital patients being treated fo...

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Hypercalcemia is a condition in which you have too much calcium in your blood. Serious cases could cause symptoms like abdominal pain, nausea, constipation, and weakness.

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Post Concussion Syndrome

Post-concussion syndrome, or post-concussive syndrome (PCS), refers to the lingering symptoms following a concussion or a mild traumatic brain injury. Symptoms vary but include headache, dizziness, and depression.

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Celiac Disease (Gluten Intolerance)

Celiac disease is a digestive disorder caused by an immune reaction to gluten. Symptoms vary but can include arthritis, fatigue, and abdominal symptoms.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.