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What causes depression and general weakness? 20 possible conditions

See a list of possible causes in order from the most common to the least.



The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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Stroke Overview

This condition is considered a medical emergency. Urgent care may be required.

A stroke (a "brain attack") is a medical emergency in which part of the brain is deprived of oxygen. This occurs when an artery that supplies oxygenated blood to the brain becomes damaged and brain cells begin to die.

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Obesity is defined as having a body mass index (BMI) of 30 or more. BMI is calculated using a person's weight and height. It can lead to other conditions like diabetes, heart disease, and cancer.

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PMS (Premenstrual Syndrome)

PMS symptoms start five to 11 days before menstruation and typically go away once menstruation begins. The cause of PMS is unknown.

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Seasonal Affective Disorder

Seasonal affective disorder (SAD) is a form of depression. People affected by SAD display symptoms of depression at the same time every year, typically during the fall and winter months. According to the America...

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Bipolar Disorder

Bipolar disorder mental illness marked by extreme from mania to depression. Bipolar disorder is also called bipolar disease or manic depression.

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Dementia Overview

Dementia may affect memory, thinking, language, judgment, and behavior. Mental impairment must affect at least two brain functions to be considered dementia.

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This condition is considered a medical emergency. Urgent care may be required.

A concussion is a mild traumatic brain injury. Usually it occurs after an impact to your head or after a whiplash-type injury. A concussion can cause many severe symptoms that affect brain function.

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Alcohol Withdrawal Syndrome

This condition is considered a medical emergency. Urgent care may be required.

Alcohol withdrawal syndrome (AWS) is the name for the symptoms that occur when a heavy drinker suddenly stops or significantly reduces their alcohol intake. With AWS, you may feel mild anxiety and fatigue. You may als...

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What is Fibromyalgia?

Fibromyalgia is a chronic disorder characterized by widespread, unexplained pain in tender points in muscles and joints, including the head, neck, and sides of hips.

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Postpartum Depression

Postpartum depression affects as many as 13 percent of new mothers. In the U.S., that's half a million women. Learn about symptoms, causes, risks, and more.

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Whiplash occurs when a person's head moves backward and then forward very suddenly with great force. This injury is most common following a car collision.

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Underactive Pituitary Gland (Hypopituitarism)

The pituitary gland releases hormones that play roles in body processes like bone growth and metabolism. An underactive pituitary can disrupt these processes. Causes may include tumors, traumatic injuries, and diseases.

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Multiple Sclerosis Overview

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. MS can cause varying symptoms that appear with a wide range of severity, from mild discomfort to complete disability.

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Endometriosis is a disorder in which the tissue that forms the lining of your uterus grows outside of your uterine cavity. The lining is called the endometrium.

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Hypercalcemia is a condition in which you have too much calcium in your blood. Serious cases could cause symptoms like abdominal pain, nausea, constipation, and weakness.

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Hashimoto's Disease

Hashimoto's disease is a condition that damages the thyroid's ability to function properly. It can cause a goiter, or enlarged thyroid, which can make the front of the neck look swollen.

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Celiac Disease (Gluten Intolerance)

Celiac disease is a digestive disorder caused by an immune reaction to gluten. Symptoms vary but can include arthritis, fatigue, and abdominal symptoms.

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In hyperparathyroidism, the parathyroid glands make too much of their hormone. It affects a number of body systems and can cause skin changes, including brittle nails and itching.

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Primary Hypothyroidism

Your thyroid gland controls the metabolism of all your cells. Your pituitary gland releases a hormone known as TSH (thyroid stimulating hormone) to stimulate your thyroid. Your thyroid then releases two hormones, T3 an...

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.