Depressed mood, Depression, Fatigue: 21 Possible Causes
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What causes depressed mood, depression and fatigue? 21 possible conditions

See a list of possible causes in order from the most common to the least.


Bipolar Disorder

Bipolar disorder is a mental illness marked by extreme shifts in mood ranging from mania to depression. It is also called bipolar disease or manic depression.

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Seasonal Affective Disorder

Seasonal affective disorder (SAD) is a form of depression. People affected by SAD display symptoms of depression at the same time every year, typically during the fall and winter months. According to the America...

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Obesity is an epidemic in the U.S. This condition puts people at a higher risk for serious diseases, such as type 2 diabetes, heart disease, and cancer.

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The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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What is Fibromyalgia?

Fibromyalgia is a chronic disorder characterized by widespread, unexplained pain in tender points in muscles and joints, including the head, neck, and sides of hips.

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PMS (Premenstrual Syndrome)

Premenstrual syndrome causes a wide variety of emotional and physical symptoms. Learn more about it.

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Anorexia Nervosa

Anorexia nervosa is an eating disorder that can result in severe weight loss. Learn more about warning signs and treatment.

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Alcohol Withdrawal Syndrome

This condition is considered a medical emergency. Urgent care may be required.

Alcohol withdrawal syndrome (AWS) is the name for the symptoms that occur when a heavy drinker suddenly stops or significantly reduces their alcohol intake. With AWS, you may feel mild anxiety and fatigue. You may als...

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This condition is considered a medical emergency. Urgent care may be required.

A concussion is a mild traumatic brain injury. Usually it occurs after an impact to your head or after a whiplash-type injury. A concussion can cause many severe symptoms that affect brain function.

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Primary Hypothyroidism

Primary hypothyroidism means your thyroid gland doesn't produce enough hormones. Learn about causes, symptoms, diagnosis, and treatments.

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Persistent depressive disorder, formerly known as dysthymia, is a form of chronic depression. Learn about its symptoms, causes, treatment, and more.

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Postpartum Depression

Postpartum depression affects as many as 13 percent of new mothers. In the U.S., that's half a million women. Learn about symptoms, causes, risks, and more.

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Whiplash occurs when a person's head moves backward and then forward very suddenly with great force. This injury is most common following a car collision.

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Underactive Pituitary Gland (Hypopituitarism)

Hypopituitarism occurs when your pituitary gland in your brain is not releasing one or more of the eight hormones it should be releasing.

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Multiple Sclerosis Overview

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. MS can cause varying symptoms that appear with a wide range of severity, from mild discomfort to complete disability.

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Post Concussion Syndrome

Post-concussion syndrome, or post-concussive syndrome (PCS), refers to the lingering symptoms following a concussion or a mild traumatic brain injury. Symptoms vary but include headache, dizziness, and depression.

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Endometriosis is a disorder in which the tissue that forms the lining of your uterus grows outside of your uterine cavity. The lining is called the endometrium.

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Hypercalcemia is a condition in which you have too much calcium in your blood.

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Hashimoto's Disease

Hashimoto's disease is a condition that damages the thyroid's ability to function properly. It can cause a goiter, or enlarged thyroid, which can make the front of the neck look swollen.

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Celiac Disease (Gluten Intolerance)

Celiac disease is a digestive disorder caused by an abnormal immune reaction to gluten. Learn about celiac disease systems, diagnosis, and treatment.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.