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What causes constipation and pain? 28 possible conditions

See a list of possible causes in order from the most common to the least.


PMS (Premenstrual Syndrome)

PMS symptoms start five to 11 days before menstruation and typically go away once menstruation begins. The cause of PMS is unknown.

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Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a chronic condition that affects the large intestine and causes many uncomfortable symptoms, such as bloating, gas, cramping, diarrhea, constipation, and pain.

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Hemorrhoids, also called piles, are swollen veins located around the anus or in the lower rectum. Internal hemorrhoids develop within the anus; external hemorrhoids develop outside of the anus. Of the two forms...

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Crohn’s Disease

Crohn's disease is a chronic bowel disease that causes severe inflammation of the digestive tract. It is associated with abdominal pain, diarrhea, and may affect your quality of life. Crohn's disease is characterized b...

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The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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Anal Fissure

An anal fissure is a small cut or tear in the skin lining the anus. Childbirth, straining during bowel movements, or bouts of constipation or diarrhea can all tear the anal lining. Anal fissures are usually not a caus...

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Anal/Rectal Abscess

An anal, or rectal, abscess occurs when a cavity in the anus becomes filled with pus. In addition to pain, it can cause fatigue, rectal discharge, and fever.

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This condition is considered a medical emergency. Urgent care may be required.

Appendicitis is inflammation of the appendix, which can be fatal if left untreated. The telltale sign is pain that usually starts as mild cramping, especially on the right side, and becomes more severe over time.

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Diverticula are bulging sacs that can appear in the lining of your large intestine. Diverticulitis occurs when these sacs get acutely infected or inflamed.

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Intestinal Obstruction

If your small or large intestine becomes blocked, fluid and digested food cannot move through. This can cause bloating, stomach cramps, and burping.

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Bleeding or spotting, increased need to urinate, tender breasts, fatigue, nausea, and missed period are signs of pregnancy.

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Colorectal (Colon) Cancer

Colorectal cancer is a cancer that originates in the rectum or colon. Both of these organs are located at the lower portion of your digestive system. The colon is at the end of the large intestine and the rectum is a...

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Peripheral Neuropathy

Peripheral neuropathy occurs when nerves malfunction because they're damaged or destroyed. You'll notice a tingling, numbness, or weakness, and possibly sweating, constipation, or diarrhea.

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Spinal Cord Injury

This condition is considered a medical emergency. Urgent care may be required.

A spinal cord injury, or damage to the spinal cord, is an extremely serious type of physical trauma. It will likely have a lasting and significant impact on most aspects of daily life. According to the Nationa...

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Proctitis is a condition in which when the lining tissue of the inner rectum becomes inflamed. The rectum is part of your lower digestive system.

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Celiac Disease (Gluten Intolerance)

Celiac disease is a digestive disorder caused by an immune reaction to gluten. Symptoms vary but can include arthritis, fatigue, and abdominal symptoms.

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Cystic Fibrosis

Cystic fibrosis is a recessive genetic disorder that affects cells that produce mucous, sweat, and digestive juices. It may cause severe problems in the lungs, pancreas, liver, and intestine

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Hypercalcemia is a condition in which you have too much calcium in your blood. Serious cases could cause symptoms like abdominal pain, nausea, constipation, and weakness.

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Hashimoto's Disease

Hashimoto's disease is a condition that damages the thyroid's ability to function properly. It can cause a goiter, or enlarged thyroid, which can make the front of the neck look swollen.

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Porphyrias are rare types of genetic blood disorders in which patients have a defect in heme production, an important part of hemoglobin. Blisters are a sign of porphyria cutanea tarda, the most common type of porphyria.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.