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What causes blood in urine and fatigue? 20 possible conditions

See a list of possible causes in order from the most common to the least.


Urinary Tract Infection

UTIs are usually caused by bacteria and can occur in any part of the urinary tract. Symptoms of upper UTIs include pain in the upper back, chills, fever, and nausea.

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Pyelonephritis is an inflammation of the kidney and upper urinary tract. Symptoms include flushed skin, back pain, fever, and nausea.

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Bladder Cancer

Bladder cancer occurs in the tissues of the bladder, which is the organ that holds urine. Fatigue, weight loss, painful or frequent urination, and abdominal or back pain are symptoms.

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Goodpasture syndrome

Goodpasture syndrome is a rare and potentially life-threatening autoimmune disease. It occurs when the immune system attacks the walls of the lungs and the tiny filtering units in the kidneys. The disorder is name...

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Rhabdomyolysis is breakdown of muscle fibers. Muscle breakdown causes the release of myoglobin into the bloodstream. Myoglobin can cause kidney damage. Symptoms include dark urine, muscle weakness, and fatigue. Abou...

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Transitional Cell Cancer (Malignant Neoplasm of Ureter)

Urine collects in the renal pelvis and is drained by the ureter into the bladder. When cancer develops in the renal pelvis or ureter, it begins in transitional cells, which line these organs.

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Glomerulonephritis occurs when blood filtering vessels in the kidneys are damaged. This may contribute to kidney failure, which causes fatigue, insomnia, itchy skin, and other symptoms.

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Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease and the most common type of lupus. One of its common symptoms is a rash on the cheeks and nose called a "butterfly rash."

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High Blood Pressure Overview

High blood pressure (hypertension) increases your risk for heart attack, stroke, coronary heart disease, and other serious health problems. Left untreated, high blood pressure can damage blood vessels and vital organs.

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What You Need to Know About Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal nocturnal hemoglobinuria is a rare disorder that causes red blood cells to break down sooner than normal. This can lead to symptoms that range from minimal (urine discoloration) to severe (stroke).

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Hemophilia A

Hemophilia A (factor VIII deficiency) is the most common form of the blood clotting disorder hemophilia. It can cause prolonged bleeding, tight joints, and unexplained bruising.

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Infective Endocarditis

Infective endocarditis is an infection of the heart, normally caused by bacteria in the blood stream. It is a serious medical condition. If left untreated, the infection can damage your heart and may even cause death.

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Endocarditis is inflammation of the inner lining of the heart. Possible symptoms of this condition include pale skin, chills, and night sweats.

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Leukemia is a cancer of the blood cells. Excessive sweating at night, constant fatigue, weight loss, bone pain, and easy bleeding or bruising are all signs of this disease.

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Sickle Cell Anemia

Sickle cell anemia is a genetic disease that causes red blood cells to have an abnormal shape, causing blood flow problems. This can lead to tissue damage and pain, as well as enlarged spleen, anemia, and other symptoms.

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Necrotizing Vasculitis

This condition is considered a medical emergency. Urgent care may be required.

Necrotizing vasculitis is the inflammation of blood vessel walls. It can interrupt blood flow, causing skin, muscle, and blood vessel damage, and death of tissues and organs. Its symptoms can affect the entire body.

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Christmas Disease (Hemophilia B)

Also called hemophilia B or factor IX hemophilia, Christmas disease is a rare genetic disorder in which your blood does not clot properly. A common symptom is unexplained or excessive bruising.

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Hypercalcemia is a condition in which you have too much calcium in your blood. Serious cases could cause symptoms like abdominal pain, nausea, constipation, and weakness.

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Idiopathic Thrombocytopenic Purpura (ITP)

Idiopathic thrombocytopenic purpura (ITP) is a disorder where the blood doesn

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Renal Cell Cancer

Renal cell carcinoma is the most common kind of kidney cancer found in adults. Often aggressive, it occurs when cancer cells grow uncontrollably in the lining of the tubules of the kidney, causing many possible symptoms.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.