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What causes blood in urine and dark urine? 11 possible conditions

See a list of possible causes in order from the most common to the least.


Urethral Stricture

Usually the urethra is wide enough for urine to flow freely through it. When it narrows, it can restrict urinary flow. This is known as a urethral stricture.

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ABO Incompatability Reaction

This condition is considered a medical emergency. Urgent care may be required.

An ABO incompatibility reaction can occur if you receive the wrong type of blood during a blood transfusion. It's rare but serious and potentially fatal.

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Bladder Stones: The Bad, the Ugly, and the Good

Bladder stones are crystals that form when concentrated urine is left in the bladder after urination, often due to dehydration or being unable to empty the bladder totally. Symptoms include painful urination and others.

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Rhabdomyolysis is breakdown of muscle fibers. Muscle breakdown causes the release of myoglobin into the bloodstream. Myoglobin can cause kidney damage. Symptoms include dark urine, muscle weakness, and fatigue. Abou...

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Glomerulonephritis is a serious illness that can be life-threatening and requires immediate treatment. The condition is sometimes called nephritis.

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Porphyrias are rare types of genetic blood disorders in which patients have a defect in heme production, an important part of hemoglobin. Blisters are a sign of porphyria cutanea tarda, the most common type of porphyria.

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Renal Cell Cancer

Renal cell carcinoma is the most common kind of kidney cancer found in adults. Often aggressive, it occurs when cancer cells grow uncontrollably in the lining of the tubules of the kidney, causing many possible symptoms.

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Goodpasture syndrome

Goodpasture syndrome is a rare and potentially life-threatening autoimmune disease. It occurs when the immune system attacks the walls of the lungs and the tiny filtering units in the kidneys. The disorder is name...

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Transitional Cell Cancer (Malignant Neoplasm of Ureter)

Urine collects in the renal pelvis and is drained by the ureter into the bladder. When cancer develops in the renal pelvis or ureter, it begins in transitional cells, which line these organs.

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Sickle Cell Anemia

Sickle cell anemia is a genetic disease that causes red blood cells to have an abnormal shape, causing blood flow problems. This can lead to tissue damage and pain, as well as enlarged spleen, anemia, and other symptoms.

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What You Need to Know About Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal nocturnal hemoglobinuria is a rare disorder that causes red blood cells to break down sooner than normal. This can lead to symptoms that range from minimal (urine discoloration) to severe (stroke).

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.