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What causes anemia and pain? 28 possible conditions

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See a list of possible causes in order from the most common to the least.


Folic Acid Deficiency Anemia

Folic acid deficiency anemia is caused by having too little vitamin B9 (folate) in your blood. Folate is necessary for your body to make new red blood cells. Red blood cells are needed to carry oxygen to your organs. I...

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Thalassemia is an inherited blood disorder that results in excessive destruction of red blood cells (anemia). Symptoms depend on its severity, and can range from minor anemia to enlargement of organs or fetal death.

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Ulcerative Colitis

Ulcerative colitis is an inflammatory bowel disease. It occurs when the lining of the large intestine (colon or bowel) and the rectum become inflamed.

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Hookworm Infections

Hookworms are parasites that affect the small intestine and lungs. The first sign of infection is usually a rash where the parasite entered the skin, followed by diarrhea.

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Megaloblastic Anemia

Megaloblastic anemia is a blood disorder marked by the appearance of very large red blood cells that crowd out healthy cells, causing anemia.

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Amebiasis is a parasitic infection, common in the tropics and caused by contaminated water. Symptoms can be severe and usually start 1-4 weeks after exposure.

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Celiac Disease (Gluten Intolerance)

Celiac disease is a digestive disorder caused by an immune reaction to gluten. Symptoms vary but can include arthritis, fatigue, and abdominal symptoms.

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Pernicious Anemia

Pernicious anemia (PA) is an autoimmune disorder in which the body fails to make enough healthy red blood cells (RBCs), resulting in vitamin B-12 deficiency. Most people experience a burning or sore tongue.

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The thyroid gland produces a hormone that controls how your cells use energy (metabolize). Hypothyroidism occurs when the body doesn't produce enough. Untreated, it can cause complications like obesity and heart disease.

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Leukemia is a cancer of the blood cells. Excessive sweating at night, fatigue, weight loss, bone pain, and easy bleeding or bruising are signs of this disease.

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Hemophilia A

Hemophilia A (factor VIII deficiency) is the most common form of the blood clotting disorder hemophilia. It can cause prolonged bleeding, tight joints, and unexplained bruising.

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Drug-Induced Immune Hemolytic Anemia

Drug-induced immune hemolytic anemia (DIIHA) is a rare blood disorder in which your immune system begins attacking your red blood cells. Symptoms include dark urine, fast heartbeat, and jaundice.

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Hemorrhoids, also called piles, are swollen veins located around the anus or in the lower rectum. Internal hemorrhoids develop within the anus; external hemorrhoids develop outside of the anus. Of the two forms...

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Rheumatoid Arthritis Overview

Rheumatoid arthritis (RA) is an autoimmune disease, a disease in which the immune system mistakes the body's own cells for invaders. In RA, the immune system attacks the synovia, the membranes lining the joints.

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Sickle Cell Anemia

Sickle cell anemia is a genetic disease that causes red blood cells to have an abnormal shape, causing blood flow problems. This can lead to tissue damage and pain, as well as enlarged spleen, anemia, and other symptoms.

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Multiple Myeloma

Multiple myeloma is a type of cancer that affects plasma cells, which are the white blood cells that make antibodies. Multiple myeloma causes groups of abnormal plasma cells to accumulate in the bones, which can lead t...

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Learn about sarcoidosis and its causes, symptoms, diagnosis, treatment, and potential complications.

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Polymyalgia Rheumatica

Polymyalgia rheumatica is an inflammatory disorder that causes pain and stiffness in various parts of the body, including the shoulders, neck, arms, thighs, and hips. The cause of this disorder is unknown.

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Dissection of the Aorta

This condition is considered a medical emergency. Urgent care may be required.

The aorta is a large artery that carries blood out of your heart. If you experience a dissection of the aorta, it means that blood has entered the wall of the artery, between the inner and middle layers. This can happe...

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Colorectal (Colon) Cancer

Colorectal cancer is a cancer that originates in the rectum or colon. Both of these organs are located at the lower portion of your digestive system. The colon is at the end of the large intestine and the rectum is a...

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.