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What causes abdominal pain, loss of appetite and unintentional weight loss? 21 possible conditions

See a list of possible causes in order from the most common to the least.



Hepatitis refers to an inflammatory condition of the liver. It's commonly caused by a viral infection, but there are other possible causes of hepatitis.

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Viral Gastroenteritis

Viral gastroenteritis, also known as the stomach flu, is caused by a number of different viruses. Its symptoms usually last for two to three days.

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Peptic Ulcer

Peptic ulcers are painful sores in the lining of the stomach, esophagus, or small intestine. Peptic ulcers are a fairly common health problem.

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Liver Cancer

Liver cancer causes destruction of liver cells and interferes with the ability of the liver to function normally. Cancer that originates in the liver can spread from the liver to other parts of the body.

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Stomach Cancer (Gastric Adenocarcinoma)

Stomach cancer occurs when cancerous cells form in the stomach lining. Because it's difficult to detect, it's often not diagnosed until it's more advanced.

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Cirrhosis is the severe scarring and poor function of the liver caused by long-term exposure to toxins such as alcohol or viral infections.

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Tuberculosis (TB) is a highly infectious disease that primarily affects the lungs. A severe and long-lasting cough, fever, and night sweats could indicate an active TB infection.

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Crohn’s Disease

Crohn's disease is a chronic bowel disease that causes severe inflammation of the digestive tract. It is associated with abdominal pain, diarrhea, and may affect your quality of life. Crohn's disease is characterized b...

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Alcoholism is also known as alcohol dependence. It occurs when you drink so much over time that your body becomes dependent on or addicted to alcohol. When this happens, alcohol use becomes the most important thing i...

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Hookworm Infections

Hookworms are parasites that affect the small intestine and lungs. The first sign of infection is usually a rash where the parasite entered the skin, followed by diarrhea.

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Addison’s Disease

Addison's disease occurs when the adrenal cortex is damaged and the adrenal glands don't produce enough of the steroid hormones cortisol and aldosterone.

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Ovarian Cancer

The ovaries are small, almond-shaped organs located on either side of the uterus that produce eggs. As the disease progresses, symptoms include back pain and indigestion.

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Celiac Disease (Gluten Intolerance)

Celiac disease is a digestive disorder caused by an immune reaction to gluten. Symptoms vary but can include arthritis, fatigue, and abdominal symptoms.

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Leukemia is a cancer of the blood cells. Excessive sweating at night, fatigue, weight loss, bone pain, and easy bleeding or bruising are signs of this disease.

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Underactive Pituitary Gland (Hypopituitarism)

The pituitary gland releases hormones that play roles in body processes like bone growth and metabolism. An underactive pituitary can disrupt these processes. Causes may include tumors, traumatic injuries, and diseases.

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Chronic Pancreatitis

Chronic, or long-term, pancreatitis is an inflammation of your pancreas that impairs your body's ability to digest food and regulate blood sugar.

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Pancreatic Cancer

Pancreatic cancer is cancer of the pancreas, an organ that secretes an enzyme that breaks down fats, carbs, and proteins. Pancreatic cancer can obstruct the outflow of bile from the liver and causes yellow skin.

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Chlamydia Infection

Chlamydia is a sexually transmitted disease that should be treated quickly in order to avoid complications. It is caused by bacteria that are usually spread through sexual contact. People with chlamydia often don't hav...

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Leishmaniasis is a parasitic disease caused by the Leishmania parasite found in sand flies.

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Brucellosis is a rare disease usually spread through ingesting infected raw meat and unpasteurized milk. Back pain, lethargy, chills, and fever may occur and could lead to complications.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.