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What causes abdominal pain, general weakness and unintentional weight loss? 26 possible conditions

See a list of possible causes in order from the most common to the least.


Peptic Ulcer

Peptic ulcers are painful sores in the lining of the stomach, esophagus, or small intestine. Peptic ulcers are a fairly common health problem.

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Hepatitis refers to an inflammatory condition of the liver. It's commonly caused by a viral infection, but there are other possible causes of hepatitis.

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Lactose Intolerance

Lactose intolerence occurs when a person's small intestine can't break down lactose, an enzyme found in dairy foods. The condition can cause many gastrointestinal symptoms.

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Stomach Ulcer

Stomach ulcers are painful sores in the stomach lining or small intestine. They occur when the mucus that protects the stomach from digestive juices is reduced.

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Liver Cancer

Liver cancer causes destruction of liver cells and interferes with the ability of the liver to function normally. Cancer that originates in the liver can spread from the liver to other parts of the body.

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Cirrhosis is the severe scarring and poor function of the liver caused by long-term exposure to toxins such as alcohol or viral infections.

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Tuberculosis (TB) is a highly infectious disease that primarily affects the lungs. A severe and long-lasting cough, fever, and night sweats could indicate an active TB infection.

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Crohn’s Disease

Crohn's disease is a chronic bowel disease that causes severe inflammation of the digestive tract. It is associated with abdominal pain, diarrhea, and may affect your quality of life. Crohn's disease is characterized b...

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Colitis is inflammation of the colon, often causing discomfort and pain in the abdomen, as well as other gastrointestinal symptoms. Colitis has many possible causes, which determine the type.

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Addison’s Disease

Addison's disease occurs when the adrenal cortex is damaged and the adrenal glands don't produce enough of the steroid hormones cortisol and aldosterone.

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Leukemia is a cancer of the blood cells. Excessive sweating at night, fatigue, weight loss, bone pain, and easy bleeding or bruising are signs of this disease.

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Hookworm Infections

Hookworms are parasites that affect the small intestine and lungs. The first sign of infection is usually a rash where the parasite entered the skin, followed by diarrhea.

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Amebiasis is a parasitic infection, common in the tropics and caused by contaminated water. Symptoms can be severe and usually start 1-4 weeks after exposure.

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Diabetes Overview

Diabetes is a group of chronic metabolic diseases caused by defects in insulin production or function. Advanced diabetes may cause stomach pain, nausea, dizziness, and cramps.

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Colorectal (Colon) Cancer

Colorectal cancer is a cancer that originates in the rectum or colon. Both of these organs are located at the lower portion of your digestive system. The colon is at the end of the large intestine and the rectum is a...

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Type 1 Diabetes

Type 1 diabetes is a chronic disease that result high levels of glucose in the blood due to a lack of insulin production. Glucose is a natural sugar that your body uses as a source of energy.

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Underactive Pituitary Gland (Hypopituitarism)

The pituitary gland releases hormones that play roles in body processes like bone growth and metabolism. An underactive pituitary can disrupt these processes. Causes may include tumors, traumatic injuries, and diseases.

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Chronic Pancreatitis

Chronic, or long-term, pancreatitis is an inflammation of your pancreas that impairs your body's ability to digest food and regulate blood sugar.

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Pancreatic Cancer

Pancreatic cancer is cancer of the pancreas, an organ that secretes an enzyme that breaks down fats, carbs, and proteins. Pancreatic cancer can obstruct the outflow of bile from the liver and causes yellow skin.

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Bladder Cancer

Bladder cancer occurs in the tissues of the bladder, which is the organ that holds urine. Fatigue, weight loss, painful or frequent urination, and abdominal or back pain are symptoms.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.