Abdominal pain, General weakness, Loss of appetite: 39 Possible Causes
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What causes abdominal pain, general weakness and loss of appetite? 39 possible conditions

See a list of possible causes in order from the most common to the least.



Bleeding or spotting, increased need to urinate, tender breasts, fatigue, nausea, and missed period are signs of pregnancy.

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PMS (Premenstrual Syndrome)

Premenstrual syndrome causes a wide variety of emotional and physical symptoms. Learn more about it.

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Hepatitis refers to an inflammatory condition of the liver. It's commonly caused by a viral infection, but there are other possible causes of hepatitis.

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Leukemia is a cancer of the blood cells. There are several types of blood cells, including red blood cells (RBCs), white blood cells (WBCs), and platelets. Generally, leukemia refers to cancers of the WBCs. Two types o...

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Peptic Ulcer

Peptic ulcers are painful sores in the lining of the stomach, esophagus, or small intestine. Peptic ulcers are a fairly common health problem.

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Alcoholic Liver Disease

Damage to the liver from excessive drinking can lead to ALD. Years of alcohol abuse cause the liver to become inflamed and swollen. This damage can also cause scarring known as cirrhosis. Cirrhosis is the final stage o...

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Hypercalcemia is a condition in which you have too much calcium in your blood.

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Infectious Mononucleosis

Infectious mononucleosis, or mono, refers to a group of symptoms usually caused by the Epstein-Barr virus (EBV).

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Celiac Disease (Gluten Intolerance)

Celiac disease is a digestive disorder caused by an abnormal immune reaction to gluten. Learn about celiac disease systems, diagnosis, and treatment.

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Hookworm Infections

Hookworms are parasites that affect the small intestine and lungs. Read more about the symptoms of this infection and treatment options.

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E. coli Infection

E. coli is a type of bacteria normally found in intestines. But certain kinds of E. coli can cause infection and severe symptoms like diarrhea and dehydration.

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Crohn’s Disease

Crohn's disease is a chronic bowel disease that causes severe inflammation of the digestive tract. It is associated with abdominal pain, diarrhea, and may affect your quality of life. Crohn's disease is characterized b...

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Ulcerative Colitis

Ulcerative colitis is an inflammatory bowel disease. It occurs when the lining of the large intestine (colon or bowel) and the rectum become inflamed.

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Pyelonephritis is an inflammation of the kidney and upper urinary tract. Symptoms include flushed skin, back pain, fever, and nausea.

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Underactive Pituitary Gland (Hypopituitarism)

Hypopituitarism occurs when your pituitary gland in your brain is not releasing one or more of the eight hormones it should be releasing.

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Cirrhosis is the severe scarring and poor function of the liver caused by long-term exposure to toxins such as alcohol or viral infections.

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Addison’s Disease

Addison's disease occurs when the adrenal cortex is damaged and the adrenal glands do not produce enough of the steroid hormones cortisol and aldosterone.

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Hepatitis A

Hepatitis A is inflammation of the liver caused by the hepatitis A virus. This is an acute (short-term) type of hepatitis, which usually requires no treatment.

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Hepatitis B

Hepatitis B is liver inflammation caused by the hepatitis B virus (HBV).

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Addisonian Crisis (Acute Adrenal Crisis)

This condition is considered a medical emergency. Urgent care may be required.

An Addisonian crisis occurs when levels of cortisol suddenly drop. Learn more about an Addisonian crisis, including symptoms, risk factors, and treatment.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.