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What causes abdominal pain, abdominal swelling and yellow skin? 20 possible conditions

See a list of possible causes in order from the most common to the least.



Gallstones are hard deposits in the gallbladder that can eventually block the exiting bile ducts. Abdominal pain, fever, itchy skin, and jaundice are symptoms.

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Hepatitis refers to an inflammatory condition of the liver. It's commonly caused by a viral infection, but there are other possible causes of hepatitis.

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Acute Pancreatitis

Acute pancreatitis is an inflammation in the pancreas, which causes pain and swelling in the upper left side of the abdomen, nausea, and burping.

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Cirrhosis is the severe scarring and poor function of the liver caused by long-term exposure to toxins such as alcohol or viral infections.

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Alcoholic Liver Disease

Damage to the liver from excessive drinking can lead to ALD. Years of alcohol abuse cause the liver to become inflamed and swollen. This damage can also cause scarring known as cirrhosis. Cirrhosis is the final stage o...

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Biliary (Bile Duct) Obstruction

A biliary obstruction blocks the bile ducts, which carry bile to the small intestine for digestion and waste removal. An obstruction can be caused by many factors, including gallstones, inflammation, cysts, or tumors.

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Thalassemia is an inherited blood disorder that results in excessive destruction of red blood cells (anemia). Symptoms depend on its severity, and can range from minor anemia to enlargement of organs or fetal death.

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G6PD Deficiency

Glucose-6-phosphate dehydrogenase(G6PD) deficiency is a genetic abnormality that leads to an inadequate amount of the necessary enzyme. Without enough G6PD, red blood cells can be destroyed, leading to anemia.

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Pancreatic Cancer

Pancreatic cancer is cancer of the pancreas, an organ that secretes an enzyme that breaks down fats, carbs, and proteins. Pancreatic cancer can obstruct the outflow of bile from the liver and causes yellow skin.

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Sickle Cell Anemia

Sickle cell anemia is a genetic disease that causes red blood cells to have an abnormal shape, causing blood flow problems. This can lead to tissue damage and pain, as well as enlarged spleen, anemia, and other symptoms.

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Drug-Induced Immune Hemolytic Anemia

Drug-induced immune hemolytic anemia (DIIHA) is a rare blood disorder in which your immune system begins attacking your red blood cells. Symptoms include dark urine, fast heartbeat, and jaundice.

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Liver Cancer

Liver cancer causes destruction of liver cells and interferes with the ability of the liver to function normally. Cancer that originates in the liver can spread from the liver to other parts of the body.

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Yellow fever

Yellow fever is a serious, potentially deadly flu-like disease spread by mosquitoes. It's found mostly in Africa and South America. Symptoms of stage 3 yellow fever include abdominal pain, vomiting, and jaundice.

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Infectious Mononucleosis

Infectious mononucleosis, or "mono," is a group of symptoms caused by the Epstein-Barr virus. One potential symptom is a pink rash that looks like the measles.

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Chlamydia Infection

Chlamydia is a sexually transmitted disease that should be treated quickly in order to avoid complications. It is caused by bacteria that are usually spread through sexual contact. People with chlamydia often don't hav...

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Hepatitis A

Hepatitis A (HAV) is a short-term type of hepatitis. It usually requires no treatment, but symptoms include fever, nausea, jaundice, and itchy skin, among others.

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Hepatitis B

Hepatitis B is liver inflammation caused by the hepatitis B virus (HBV). It can be chronic or acute, but most cases are chronic. This disease is easily spread through blood, saliva, and other body fluids.

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Hepatitis E

The hepatitis E virus is spread most often by contaminated drinking water. It is different from the hep-A virus but the symptoms are similar. Most cases clear up on their own after a few weeks. In other cases, the viru...

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Hepatitis C

Hepatitis C is a disease that causes inflammation and infection in the liver. Symptoms of chronic cases may not be obvious at first, whereas acute hepatitis C sets in quickly after exposure to the virus.

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Hepatitis D

Hepatitis D is an infection of the hepatitis D virus that causes your liver to swell and is uncommon in the United States. It is almost always contracted by people with hepatitis B.

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This feature is for informational purposes only and should not be used to diagnose.
Please consult a healthcare professional if you have health concerns.