Every year, thousands of people experience interactions between prescribed drugs and over-the-counter drugs, or between drugs and herbal products. Other unexpected interactions can occur between drugs and certain foods or health conditions. Assessing how much you know about these potential interactions and learning what you can do to prevent them can help keep you safe. Take this quiz, based on information from the American Pharmacists Association's publication "Pocket Guide to Evaluations of Drug Interactions" and the Food and Drug Administration (FDA).
A variety of substances can alter a drug's effects.
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Some interactions reduce a drug's effectiveness; others can dramatically increase a drug's effect or cause side effects. For example, alcohol consumed along with acetaminophen can damage the liver. Viagra and nitrites or nitrates can cause low blood pressure (hypotension), a sometimes fatal condition. The organ transplant drug cyclosporin taken with St. John's wort can cause sudden rejection of the transplanted organ. Warfarin, a blood thinner, and either vitamin E or aspirin may cause hemorrhaging.
A drug-drug interaction occurs when two drugs together produce an unwanted and potentially dangerous outcome or side effect.
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Problems often occur between prescribed medication and OTC drugs. It is important to read the label on any OTC drug you take. The label includes information on possible drug interactions. Drug labels can change, so it's critical to look at the label each time you buy a new supply. For example, taking an antihistamine and a sedative at the same time can make you very drowsy. This can be dangerous if you are driving or need to operate machinery.
A drug-food interaction occurs when a medication interacts with a substance in a food or beverage.
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Orange juice or another acidic beverage can hinder your absorption of nicotine from nicotine gum. Grapefruit juice should not be taken with some blood pressure medications or cyclosporin (taken by organ transplant patients), according to the American Pharmaceutical Association (APA). Dairy products, antacids and vitamins with iron can make antibiotics less effective. Eating cheese or drinking wine may cause a severe hypertensive reaction when taking when taking a monoamine oxidase inhibitor. Alcohol may increase the effect of when taking a sedative or drug to ease anxiety.
A drug-alcohol interaction can lead to extreme drowsiness and other effects.
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Drinking alcohol when taking a sedative, for example, can make you feel tired or slow your reaction time, the FDA says. Having three or more drinks a day when taking acetaminophen can lead to liver damage. Alcohol with aspirin, ibuprofen or naproxen may cause ulcers.
A drug-condition interaction occurs when a medication is harmful to someone with certain medical conditions.
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If you have kidney disease, your condition could be made worse if you take ibuprofen. If you have high blood pressure, your condition could worsen if you take a nasal decongestant or use a nasal spray. Antihistamines can worsen a problem with urination caused by prostate problems. Sleeping pills can complicate sleep apnea or emphysema.
Over-the-counter (OTC) and prescription medications don't interact with herbal remedies and supplements.
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When your doctor prescribes a new drug, the FDA says, discuss all OTC and prescription drugs, dietary supplements, vitamins, botanicals, minerals and herbals you take, as well as the foods you eat. Any of these may interact with the new medication.
Using the same pharmacy for all your prescriptions can help reduce drug interactions.
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Doing so lets your pharmacist check for interactions.
Thoroughly reading the labels of all OTC medications before taking them can help you avoid interactions.
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OTC drug labels contain information about ingredients, uses, warnings and directions, as well as information about possible drug interactions, the FDA says. Different OTC drugs may contain the same active ingredient. If you are taking more than one OTC drug, pay attention to the active ingredients used in the products to avoid taking too much of a particular ingredient.
Talk to your pharmacist or health care provider before taking any new OTC medication.
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Read the label first, and call your pharmacist or health care provider if you have questions about whether it's safe to take with other medications, vitamins or herbal products you already take.
If you experience a drug interaction, call your health care provider.
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