Transitional Cell Cancer of t... Health Article

Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter

Recurrenttransitional cell cancer of the renal pelvis and ureter is cancer that has recurred (come back) after it has been treated. The cancer may come back in the renal pelvis, ureter, or other parts of the body.

Treatment Option Overview

There are different types of treatment for patients with transitional cell cancer of the renal pelvis and ureter.

Different types of treatments are available for patients with transitional cell cancer of the renal pelvis and ureter. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. Before starting treatment, patients may want to think about taking part in a clinical trial. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment.

Clinical trials are taking place in many parts of the country. Information about ongoing clinical trials is available from the NCI Web site. Choosing the most appropriate cancer treatment is a decision that ideally involves the patient, family, and health care team.

One type of standard treatment is used:

Surgery

One of the following surgical procedures may be used to treat transitional cell cancer of the renal pelvis and ureter:

• Nephroureterectomy: Surgery to remove the entire kidney, the ureter, and the bladder cuff (tissue that connects the ureter to the bladder).

• Segmental resection of the ureter: A surgical procedure to remove the part of the ureter that contains cancer and some of the healthy tissue around it. The ends of the ureter are then reattached. This treatment is used when the cancer is superficial and in the lower third of the ureter only, near the bladder.

Other types of treatment are being tested in clinical trials. These include the following:

Fulguration

Fulguration is a surgical procedure that destroys tissue using an electric current. A tool with a small wire loop on the end is used to remove the cancer or to burn away the tumor with electricity.

Segmental resection of the renal pelvis

This is a surgical procedure to remove localized cancer from the renal pelvis without removing the entire kidney. Segmental resection may be done to save kidney function when the other kidney is damaged or has already been removed.

Laser surgery

A laser beam (narrow beam of intense light) is used as a knife to remove the cancer. A laser beam can also be used to kill the cancer cells. This procedure may be called laser therapy or laser fulguration.

Regional chemotherapy and regional biologic therapy

Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping the cells from dividing. Biologic therapy is a treatment that uses the patient's immune system to fight cancer; substances made by the body or made in a laboratory are used to boost, direct, or restore the body's natural defenses against cancer. Regional treatment means the anticancer drugs or biologic substances are placed directly into an organ or a body cavity such as the abdomen, so the drugs will affect cancer cells in that area. Clinical trials are studying the effectiveness of chemotherapy or biologic therapy using drugs placed directly into the renal pelvis or the ureter.

This summary section refers to specific treatments under study in clinical trials, but it may not mention every new treatment being studied. Information about ongoing clinical trials is available from the NCI Web site.

Treatment Options for Transitional Cell Cancer of the Renal Pelvis and Ureter

Localized Transitional Cell Cancer of the Renal Pelvis and Ureter

Treatment of localizedtransitional cell cancer of the renal pelvis and ureter may include the following:

• Surgery (nephroureterectomy or segmental resection of ureter).

• A clinical trial of fulguration.

• A clinical trial of laser surgery.

• A clinical trial of segmental resection of the renal pelvis.

• A clinical trial of regional chemotherapy.

• A clinical trial of regionalbiologic therapy.

This summary section refers to specific treatments under study in clinical trials, but it may not mention every new treatment being studied. Information about ongoing clinical trials is available from the NCI Web site.

Regional Transitional Cell Cancer of the Renal Pelvis and Ureter

Treatment of regionaltransitional cell cancer of the renal pelvis and ureter is usually done in a clinical trial. Information about ongoing clinical trials is available from the NCI Web site.

Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter

Treatment of metastatictransitional cell cancer of the renal pelvis and ureter is usually done in a clinical trial, which may include chemotherapy. Information about ongoing clinical trials is available from the NCI site.

Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter

Treatment of recurrenttransitional cell cancer of the renal pelvis and ureter is usually done in a clinical trial, which may include chemotherapy. Information about ongoing clinical trials is available from the NCI Web site.