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trifluoperazine Images

Generic Name: trifluoperazine

Brand Names: Stelazine

There is an FDA Alert for this drug. Click here to view it.

    Increased Mortality in Geriatric Patients with Dementia-related Psychosis
  • Geriatric patients with dementia-related psychosis treated with antipsychotic agents are at an increased risk of death.
  • Analyses of 17 placebo-controlled trials in geriatric patients mainly receiving atypical antipsychotic agents revealed an approximate 1.6- to 1.7-fold increase in mortality compared with that in patients receiving placebo.
  • Most fatalities appeared to result from cardiovascular-related events (e.g., heart failure, sudden death) or infections (mostly pneumonia).
  • Observational studies suggest that conventional or first-generation antipsychotic agents also may increase mortality in such patients.
  • Antipsychotic agents, including trifluoperazine, are not approved for the treatment of dementia-related psychosis.

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