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stavudine Images

Generic Name: stavudine

Brand Names: Zerit, Zerit XR

There is an FDA Alert for this drug. Click here to view it.

  • Lactic acidosis and severe hepatomegaly with steatosis (including some fatalities) reported rarely in patients receiving nucleoside reverse transcriptase inhibitors (NRTIs) alone or in conjunction with other antiretrovirals. (See Lactic Acidosis and Severe Hepatomegaly with Steatosis under Cautions.)
  • Fatal lactic acidosis reported in pregnant women receiving stavudine and didanosine with other antiretrovirals. Stavudine in conjunction with didanosine should be used with caution in pregnant women and only if potential benefits outweigh potential risks. (See Pregnancy under Cautions.)
  • Fatal and nonfatal pancreatitis reported in patients receiving stavudine and didanosine with or without hydroxyurea. (See Pancreatitis under Cautions.)

REMS:

FDA approved a REMS for stavudine to ensure that the benefits of a drug outweigh the risks. However, FDA later rescinded REMS requirements. See the FDA REMS page ([Web]) or the ASHP REMS Resource Center ([Web]).

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