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propoxyphene Images

Generic Name: propoxyphene

Brand Names: Darvon-N, Darvon, Propoxyphene Hydrochloride, PP-Cap

There is an FDA Alert for this drug. Click here to view it.

    Risk of Fatal Overdosage
  • Numerous reports of intentional or accidental overdose of propoxyphene preparations, alone or in combination with other CNS depressants (e.g., alcohol); death may occur within 1 hour of overdose.
  • Many of the deaths have occurred in patients with a history of emotional disturbances or suicidal ideation or attempts and/or with concomitant use of CNS depressants (e.g., sedatives, tranquilizers, skeletal muscle relaxants, antidepressants, alcohol).
  • Do not use in patients who are suicidal or have a history of suicidal ideation.

    Interactions with CYP3A4 Inhibitors
  • Concomitant use of potent CYP3A4 inhibitors (e.g., amiodarone, aprepitant, clarithromycin, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, troleandomycin, verapamil) may increase plasma concentrations of propoxyphene.
  • Monitor patients receiving any CYP3A4 inhibitor concomitantly with propoxyphene carefully for an extended period of time and adjust dosage if needed.

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