Risk of developing potentially serious cardiac effects. (See Cardiovascular Effects under Cautions.) Pericardial effusion, progressing to tamponade may occur and angina pectoris may be exacerbated. Reserve for hypertensive patients who do not respond to maximum therapeutic doses of a diuretic and 2 other antihypertensive agents.
In animal studies, minoxidil caused myocardial lesions and other adverse cardiac effects.
Administer under close supervision, usually concomitantly with a β-adrenergic blocking agent and a diuretic, usually a loop diuretic, to prevent adverse effects.
Hospitalize and monitor patients with malignant hypertension or those already receiving concomitant guanethidine therapy to prevent too rapid or severe orthostatic decreases in BP.
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