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itraconazole Images

Generic Name: itraconazole

Brand Names: Onmel, Sporanox

There is an FDA Alert for this drug. Click here to view it.

  • Itraconazole capsules should not be used for treatment of onychomycosis in patients with evidence of ventricular dysfunction, including CHF or history of CHF.
  • Discontinue itraconazole if signs or symptoms of CHF occur. IV itraconazole (no longer commercially available in the US) caused negative inotropic effects in healthy individuals and in dogs.
  • Concomitant use with cisapride (currently commercially available in the US only under a limited-access protocol), pimozide, quinidine, dofetilide, or levomethadyl (no longer commercially available in the US) is contraindicated. Itraconazole is a potent inhibitor of CYP3A4 isoenzymes and may increase plasma concentrations of drugs metabolized by CYP3A4. Serious cardiovascular events, including QT prolongation, torsades de pointes, ventricular tachycardia, cardiac arrest, and/or sudden death have occurred in patients using cisapride, pimozide, levomethadyl, or quinidine concomitantly with itraconazole and/or other CYP3A4 inhibitors. (See Interactions.)

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