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Drug Notebook

FDA Alerts

  • Itraconazole capsules should not be used for treatment of onychomycosis in patients with evidence of ventricular dysfunction, including CHF or history of CHF. Discontinue itraconazole if signs or symptoms of CHF occur. IV itraconazole has caused negative inotropic effects in healthy individuals and in dogs.
  • Concomitant use with cisapride, pimozide, quinidine, or dofetilide is contraindicated. Itraconazole is a potent inhibitor of CYP3A4 isoenzymes and may increase plasma concentrations of drugs metabolized by CYP3A4. Serious cardiovascular events, including QT prolongation, torsades de pointes, ventricular tachycardia, cardiac arrest, and/or sudden death have occurred in patients using cisapride, pimozide, or quinidine concomitantly with itraconazole and/or other CYP3A4 inhibitors. (See Interactions.)

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itraconazole
(i tra KO na zole)
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JANSSEN SPORANOX 100 | 100 mgJANSSEN SPORANOX 100   100 mg
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