Drugs A - Z

hydroxyurea Images

Generic Name: hydroxyurea

Brand Names: Mylocel, Hydrea, Droxia

There is an FDA Alert for this drug. Click here to view it.

    Toxicity
  • Highly toxic drug with a low therapeutic index.
  • Possible severe, sometimes life-threatening or fatal, adverse effects.
    Limit to Qualified Personnel
  • Administer only under supervision of qualified clinicians experienced in use of cytotoxic therapy. (See Adequate Patient Evaluation and Monitoring under Cautions.)
    Carcinogenicity
  • Hydroxyurea is genotoxic and is a presumed human carcinogen; also, mutagenic and clastogenic in vitro.
  • Secondary leukemias have been reported in patients receiving long-term therapy for myeloproliferative disorders (e.g., polycythemia vera, thrombocythemia).
  • Carefully consider risks of developing secondary malignancies against the benefits of therapy. (See Carcinogenicity under Cautions.)

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