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fludarabine Images

Generic Name: fludarabine

Brand Names: Oforta, Fludarabine Phosphate Novaplus

There is an FDA Alert for this drug. Click here to view it.

    Myelosuppression
  • Risk of severe bone marrow suppression. (See Hematologic Effects under Cautions.)
    Hemolysis
  • Possible life-threatening and sometimes fatal autoimmune hemolytic anemia after one or more courses of fludarabine therapy. Evaluate and monitor patients closely for hemolysis. (See Hematologic Effects under Cautions.)

    Neurotoxicity
  • Possible severe neurologic effects (e.g., blindness, coma, death) following administration of high dosages (96 mg/m2; approximately 4 times the currently recommended dosage for chronic lymphocytic leukemia [CLL]) to patients with acute leukemia. Risk of CNS effects in patients receiving relatively low dosages (e.g., equivalent to those currently recommended for CLL). (See Neurotoxicity under Cautions.)

      Pulmonary Toxicity
    • Possible fatal pulmonary toxicity associated with concomitant use of fludarabine and pentostatin. Do not use fludarabine concomitantly with pentostatin. (See Specific Drugs under Interactions.)
      Experience of Supervising Clinician
    • Use under supervision of a qualified clinician experienced in therapy with antineoplastic agents.

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