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dasatinib Images

Generic Name: dasatinib

Brand Names: Sprycel

There is an FDA Alert for this drug. Click here to view it.

Special Alerts:

[Posted 10/11/2011] ISSUE: FDA notified healthcare professionals that dasatinib (Sprycel) may increase the risk of a rare but serious condition in which there is abnormally high blood pressure in the arteries of the lungs (pulmonary arterial hypertension [PAH]). Symptoms of PAH may include shortness of breath, fatigue, and swelling of the body (such as the ankles and legs). In reported cases, patients developed PAH after starting dasatinib, including after more than one year of treatment.

Information about this risk has been added to the Warnings and Precautions section of the dasatinib drug label.

BACKGROUND: Dasatinib is used to treat certain adult patients with Philadelphia chromosome-positive chronic myeloid leukemia (CML) or acute lymphoblastic leukemia (ALL).

RECOMMENDATION:Healthcare professionals should evaluate patients for signs and symptoms of underlying cardiopulmonary disease prior to starting dasatinib and also during treatment. If PAH is confirmed, dasatinib should be permanently discontinued. For more information visit the FDA website at: [Web] and [Web].

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