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dantrolene Images

Generic Name: dantrolene

Brand Names: Dantrium, Dantrolene Sodium

There is an FDA Alert for this drug. Click here to view it.

    Hepatic Effects of Oral Dantrolene
  • Risk of developing potentially fatal, hepatic injury (e.g., hepatitis); should not be used for unlabeled indications.
  • Females, patients >35 years of age, and those receiving other drugs (especially estrogens) concomitantly are at greatest risk.
  • Risk of symptomatic hepatitis (fatal and nonfatal) may be dose dependent; incidence much higher at dosages ≥800 mg daily than at dosages ≤400 mg daily. Even intermittent, short courses at higher dosages associated with increased risk. Use lowest possible effective dose.
  • Overt hepatitis most frequently observed between 3rd and 12th month of therapy.
  • Frequently monitor hepatic function. (See Hepatic Effects under Cautions.)
  • If benefits are not evident within 45 days, discontinue therapy.

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