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capecitabine Images

Generic Name: capecitabine

Brand Names: Xeloda

There is an FDA Alert for this drug. Click here to view it.

    Alterations in Anticoagulant Effects
  • Altered coagulation parameters (e.g., increased PT, increased INR) and/or bleeding, sometimes fatal, reported in patients, with or without liver metastases, receiving capecitabine concomitantly with coumarin-derivative anticoagulants. Generally occurs within several days to months following initiation of therapy, but has been reported within 1 month following discontinuance of therapy. (See Coagulopathy under Cautions and also see Specific Drugs under Interactions.)
  • Age >60 years and diagnosis of cancer may independently increase risk of coagulopathy.
  • Monitor anticoagulant response (PT or INR) frequently in patients receiving concomitant capecitabine and oral coumarin-derivative therapy; adjust anticoagulant dosage accordingly.

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