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Drug Notebook

FDA Alerts

    Alterations in Anticoagulant Effects
  • Altered coagulation parameters (e.g., increased PT, increased INR) and/or bleeding, sometimes fatal, reported in patients, with or without liver metastases, receiving capecitabine concomitantly with coumarin-derivative anticoagulants. Generally occurs within several days to months following initiation of therapy, but has been reported within 1 month following discontinuance of therapy. (See Coagulopathy under Cautions and also see Specific Drugs under Interactions.)
  • Age >60 years and diagnosis of cancer may independently increase risk of coagulopathy.
  • Monitor anticoagulant response (PT or INR) frequently in patients receiving concomitant capecitabine and oral coumarin-derivative therapy; adjust anticoagulant dosage accordingly.

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capecitabine
(ka pe SITE a been)
XELODA / 500 | 500 mgXELODA / 500   500 mg
bottle, 240 each Capecitabine 500mg, Oral tablet, peach, biconvex, oblong-shaped, side 1:XELODA, side 2:500
XELODA / 150 | 150 mgXELODA / 150   150 mg
bottle, 60 each Capecitabine 150mg, Oral tablet, peach, biconvex, oblong-shaped, side 1:XELODA, side 2:150
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