Drugs A - Z
Valerian (Valeriana officinalis L.)
Generic Name: valerian
Brand Names: Valerian Root
CategoryHerbs & Supplements
All-heal, amantilla, balderbrackenwurzel, baldrian, baldrianwurzel, baldrion, Belgian valerian, blessed herb, capon's tail, common valerian, English valerian, fixed valerian-hops extract combination Ze91019, fragrant valerian, garden heliotrope, garden valerian, German valerian, great wild valerian, heliotrope, herba benedicta, Indian valerian, Jacob's ladder, Japanese valerian, katzenwurzel, laege-baldrian, Li 156, Mexican valerian, Nervex®, Neurol®, Orasedon®, pacific valerian, phu, phu germanicum, phu parvum, pinnis dentatis, racine de valèriane, radix valerian, red valerian, Sanox-N®, Sedonium®, setewale capon's tail, setwall, setwell, tagara, theriacaria, Ticalma®, Valeriana edulis, Valeriana faurieri, Valeriana foliis pinnatis, Valeriana jatamansi, Valeriana radix, Valeriana sitchensis, Valeriana wallichii, valariana, Valerianaceae (family), Valerianaheel®, valeriane, Valmane®, vandal root, Vermont valerian, wild valerian.
Valerian is an herb native to Europe and Asia that currently grows in most parts of the world. The name is believed to come from the Latin word "valere" meaning to be healthy or strong. The root of the plant is believed to contain its active constituents. Use of valerian as a sedative and anti-anxiety treatment has been reported for more than 2,000 years. For example, in the 2nd Century AD, Galen recommended valerian as a treatment for insomnia. Related species have been used in traditional Chinese and Indian Ayurvedic medicine. Preparations for use on the skin have been used to treat sores and acne, and valerian by mouth has been used for other conditions such as digestive problems, flatulence (gas), congestive heart failure, urinary tract disorders, and angina (chest pain).
Valerian extracts became popular in the United States and Europe in the mid-1800s and continued to be used by both physicians and the lay public until it was widely replaced by prescription sedative drugs. Valerian remains popular in North America, Europe, and Japan and is widely used to treat insomnia and anxiety. Although the active ingredients in valerian are not known, preparations are often standardized to the content of valerenic acid.
EvidenceDISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Several studies of valerian have reported benefits in reducing non-specific anxiety symptoms. Valerian has also been given in combination with other herbs, such as passionflower and St. John's wort to treat anxiety. However, most studies have been small and poorly designed. More research is needed before a recommendation can be made.
There is not enough available scientific evidence in this area.
Several studies in adults suggest that valerian improves the quality of sleep and reduces the time to fall asleep (sleep latency), for up to four to six weeks. Ongoing nightly use may be more effective than single-dose use, with increasing effects over four weeks. Better effects have been found in poor sleepers. However, most studies have not used scientific ways of measuring sleep improvements, such as sleep pattern data in a sleep laboratory.
There is not enough available scientific evidence in this area.
Although valerian has not been studied specifically as a sedative, evidence from studies conducted for other purposes suggests that valerian may not have significant sedative effects when used at recommended doses. Therefore, even though valerian could be helpful as a sleep aid, it does not appear to cause sedation.
TraditionWARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Acne, amenorrhea (lack of menstruation), angina (chest pain), anorexia, anti-seizure, antiperspirant, antiviral, arthritis, asthma, bloating, bronchospasm, congestive heart failure, constipation, cough, cramping (abdominal, pelvic, menstrual), digestive problems, diuretic (increase urine flow), dysmenorrhea (pain with menstrual cycle), emmenagogue (stimulation of menstrual blood flow), epilepsy, fatigue, fever, flatulence (gas), hangovers, headache, heart disease, heartburn, high blood pressure, HIV, hot flashes, hypochondria, irritable bowel syndrome, liver disorders, measles, memory enhancement, migraine, mood enhancement, muscle pain/spasm/tension, nausea, nerve pain, pain relief, restlessness, stomach ulcers, premenstrual syndrome (PMS), restless leg syndrome, rheumatic pain, skin disorders, stress, urinary tract disorders, vaginal infections, vertigo, viral gastroenteritis, vision problems, withdrawal from tranquilizers.
Adults (18 years and older)
Studied doses range from 400 to 900 milligrams of an aqueous or aqueous-ethanolic extract (corresponding to 1.5 to 3 grams of herb), taken 30 to 60 minutes before going to bed. Valerian has historically been used in the form of a tea (1.5 to 3 grams root steeped for five to 10 minutes in 150 milliliters boiling water), although this formulation has not been studied. Doses of 300-1,800 milligrams of valerian have also been taken by mouth in capsule form.
Children (younger than 18 years)
There is not enough scientific evidence to recommend the use of valerian in children.
SafetyDISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.
People with allergies to plants in the Valerianaceae family may be allergic to valerian.
Side Effects and Warnings
Studies report that valerian is generally well tolerated for up to four to six weeks in recommended doses. Valerian has occasionally been reported to cause headache, excitability, stomach upset, uneasiness, dizziness, unsteadiness (ataxia), and low body temperature (hypothermia). Chronic use (longer than two to four months) may result in insomnia. Slight reductions in concentration or complicated thinking may occur for a few hours after taking valerian. Use caution if driving or operating heavy machinery. Some research suggests that valerian may not cause sedation.
A drug "hangover" effect has been reported in people taking high doses of valerian extracts. "Valerian withdrawal" may occur if you stop using valerian suddenly after chronic high-dose use, including confusion (delirium) and rapid heartbeat. These symptoms may improve with the use of benzodiazepines such as lorazepam (Ativan®). Although unknown, valerian may have similar brain activity as benzodiazepines (which are commonly used to treat anxiety and insomnia), through effects on the brain chemical gamma-amino-butyric-acid (GABA).
Valerian has been on the U.S. Food and Drug Administration's (FDA's) GRAS (Generally Regarded as Safe) list, and no deaths due to overdose are currently available.
Liver toxicity has been associated with some multi-herb preparations that include valerian. However, the contribution of valerian itself is not clear due to the potential liver toxicity of other included ingredients and the possibility of contamination with unlisted herbs.
Pregnancy & Breastfeeding
Because there is limited human safety data, valerian use during pregnancy and breastfeeding is not recommended. There are theoretical concerns over the adverse effects of chemical components that are toxic in laboratory studies.
Interactions with Drugs
Based on animal and human studies, valerian may increase the amount of drowsiness caused by some drugs, although this is an area of controversy. Examples include benzodiazepines such as lorazepam (Ativan®) or diazepam (Valium®), barbiturates such as phenobarbital, narcotics such as codeine, some antidepressants, and alcohol. Caution is advised while driving or operating machinery. In one human study, a combination of valerian and the beta-blocker drug propranolol (Inderal®) reduced concentration levels more than valerian alone. A brief episode of confusion was reported in one patient using valerian with loperamide (Imodium®) and St. John's wort (Hypericum perforatum L.).
An episode of agitation, anxiety, and self-injury was reported in a patient after taking valerian with fluoxetine (Prozac®) for a mood disorder (the person was also drinking alcohol). In theory, valerian may interact with anti-seizure medications, although human data is lacking. Valerian tinctures may contain high alcohol content (15-90%) and theoretically may cause vomiting if taken with metronidazole (Flagyl®) or disulfiram (Antabuse®). Valerian may interact with certain drugs metabolized by the liver or vasopressin.
Interactions with Herbs & Dietary Supplements
Based on theoretical concerns, valerian may increase the amount of drowsiness caused by some herbs or supplements.
A brief episode of confusion was reported in one patient during use of valerian with loperamide (Imodium®) and St. John's wort (Hypericum perforatum L.). Nausea, sweating, muscle cramping, weakness, elevated pulse, and high blood pressure were reported after a single dose of a combination product with St. John's wort, kava, and valerian. Valerian may interact with certain herbs and supplements that are metabolized by the liver.
This information is based on a professional level monograph edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ethan Basch, MD (Memorial Sloan-Kettering Cancer Center); Samuel Basch, MD (Mt. Sinai Medical Center); Steven Bratman, MD; Cathi Dennehy, PharmD (University of California, San Francisco); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Gerald Gianutsos, PhD (University of Connecticut School of Pharmacy); Taras Hollyer, BSc, MSc (Canadian College of Naturopathic Medicine); Charles Holmes, MD (Harvard Medical School); Adrianne Rogers, MD (Boston University Medical Center); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Mamta Vora, PharmD (Northeastern University); Wendy Weissner, BA (Natural Standard Research Collaboration).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
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