Drugs A - Z

Spleen extract

Generic Name: spleen extract

Category

Herbs & Supplements

Synonyms

Bovine spleen, predigested spleen extract, raw spleen, spleen, spleen concentrate, spleen factors, spleen peptides, spleen polypeptides, splenopentin, tetrapeptide tuftsin, tuftsin, tuftsin (L-prolyl-L-arginine), tuftsin (Thr-Lys-Pro-Arg), water-soluble spleen extract.

Background

The spleen is a fist-sized organ located under the lower left side of the rib cage that removes worn-out red blood cells and platelets, produces certain types of white blood cells, and destroys bacteria and cellular debris. Spleen extract primarily comes from the spleens of cows or pigs.

The primary use of spleen extracts is after a splenectomy, or removal of the spleen. Preliminary studies indicate that spleen extract may stimulate the immune system in conditions such as HIV/AIDS, leukemia, leprosy, Crohn's disease, and sickle cell disease. However, there are no high-quality clinical trials currently available on the use of spleen extract.

Some concern has been raised about the safety of spleen extract, as it is made of animal spleens, which may be infected with prion (proteinaceous infectious proteins) diseases. Although there are currently no available reports of diseases such as bovine spongiform encephalitis (BSE, or "mad cow disease") attributed to the consumption of spleen extract, the U.S. Food and Drug Administration (FDA) still cautions against use of any animal organ extract. It is not clear how the processing of spleen extract affects the transmission of these diseases.

Evidence

DISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Tradition

WARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Antibacterial, antifungal, antimicrobial, antioxidant, bleeding disorders, cancer, celiac disease, common cold, Crohn's disease, dermatitis herpetiformis, emotional disorders, fatigue, glomerulonephritis (inflammation of the kidney), graft-versus-host disease (prevention), HIV/AIDS, Hodgkin's disease, immunomodulation, influenza, leprosy, leukemia, pulmonary (lung) conditions, quality of life in HIV patients, radiation side effects, rheumatoid arthritis, sarcoidosis, sickle cell disease, spleen disorders (lymphoproliferative diseases), supplementation in preterm and very low birthweight infants, systemic lupus erythematosus (autoimmune disease), thrombocytopenia (low platelet count), ulcerative colitis (inflammatory bowel disease), vasculitis (inflamed blood vessels).

Dosing

Adults (18 years and older):

There is no proven safe or effective dose for spleen extract. Nonetheless, 150-300 milligrams two or three times daily has been used.

Children (younger than 18 years):

There is no proven safe or effective dose for spleen extract, and use in children is not recommended.

Licensed from
The Healthline Site, its content, such as text, graphics, images, search results, HealthMaps, Trust Marks, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.
Advertisement