Drugs A - Z

Maitake mushroom (Grifola frondosa)

treats Immune enhancement, Cancer, and Diabetes

Generic Name: Maitake mushroom extract.

Category

Herbs & Supplements

Synonyms

Beta-glucan, cloud mushroom, dancing mushroom, grifolan, Grifron Pro Maitake D-Fraction Extract®, king of mushroom, Maitake Gold 404®, MDF, MD-fraction, My-take.

Background

Maitake is the Japanese name for the edible fungus Grifola frondosa, which is characterized by a large fruiting body and overlapping caps. Maitake has been used traditionally both as a food and for medicinal purposes. Polysaccharide constituents of maitake have been associated with multiple bioactive properties in animal studies. Extracts of maitake mushroom, and particularly the beta-glucan polysaccharide constituent, have been associated with immune modulation in pre-clinical studies and are hypothesized to exert anti-tumor effects as a result of their immune properties. Human data are limited and at this time, there is insufficient evidence to recommend for or against the use of oral maitake for any indication.

Evidence

DISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

Cancer: Early studies in the laboratory as well as in humans suggest that beta-glucan extracts from maitake may increase the body's ability to fight cancer. However, these studies have not been well designed and better research is needed before the use of maitake for cancer can be recommended.
Grade: C

Diabetes: In animal studies, maitake extracts are reported to lower blood sugar levels. However, little is known about the effect of maitake on blood sugar in humans.
Grade: C

Immune enhancement: Animal and laboratory studies suggest that beta-glucan extracts from maitake may alter the immune system. However, no reliable studies in humans are available.
Grade: C

Tradition

WARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Antifungal, anti-infective, antitumor, antiviral, arthritis, bacterial infection, diagnostic agent, high blood pressure, high cholesterol, HIV, liver inflammation (hepatitis), weight loss.

Dosing

Adults (over 18 years old)

As capsules, tablets, or liquid extract, doses of beta-glucan from maitake range from 0.5 to 1 milligram per kilogram daily, taken in divided doses. Few studies in humans are available, and it is not known what doses may be safe or effective.

It is not known what doses of raw mushroom are safe or effective.

Children (under 18 years old)

Little information is available about the safety of maitake in children. Therefore, its use cannot be recommended.

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