Drugs A - Z
Generic Name: Krebiozen
CategoryHerbs & Supplements
1-methyl-2-amino-imidazol-4-one, 1-methylglycocyamidine, 1-methylhydantoin, 1-methylhydantoin-2-imide, 2-imino-1,5-dihydro-1-methyl-4H-imidazol-4-one, 2-amino-1,5-dihydro-1-methyl, 2-imino-1,5-dihydro-1-methyl-4H-imidazol-4-one, 2-imino-1-methyl-4-imidazolidinone, 2-imino-1-methylimidazolidin-4-one, 4H-imidazol-4-one,2-amino-1,5-dihydro-1-methyl, 45514-66-7, 60-27-5, 82016-55-5, AI3-15321, AIDS166904, C00791, CHEMBANK986, creatine monohydrate, creatinine, creatinine (VAN) (8CI), EINECS 200-466-7, heated creatinine, mineral oil, NISTC60275, NSC-8752 injections, NSC13123, substance X, ZINC00895382, ZINC00967189.
It is claimed that krebiozen, originally called substance X, came from horses inoculated with Actinomyces bovis by Dr. Stevan Durovic. Durovic claimed that krebiozen had been useful in the treatment of spontaneous cancer, mainly in cats and dogs. It is unclear what kreboizin really contained; in some cases it was found to be creatine monohydrate and in other cases it contained mineral oil and l-methylhydantoin, a product of heating creatine monohydrate.
Several studies have failed to show beneficial results from kreboizen. Reports published by the Krebiozen Foundation found improvement in cancer patients, but these results were disproven by the U.S. Food and Drug Administration (FDA) and the National Cancer Institute. Dr. Andrew Ivy (University of Illinois), Dr. Stevan Durovic, and Marko Durovic were brought to trial for violations of FDA regulations. There is currently no scientific proof that krebiozen is a viable treatment option for high blood pressure, cancer remission or any other condition.
EvidenceDISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
TraditionWARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Bilateral pneumonectomy (surgical removal of lung), bladder cancer, cancer (breast, cervical), high blood pressure.
Adults (over 18 years old)
There is no proven safe or effective dose for kreboizen in adults.
Children (under 18 years old)
There is no proven safe or effective dose for kreboizen, and use in children is not recommended.
SafetyDISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.
Avoid in individuals with a known allergy or hypersensitivity to creatine monohydrate.
Side Effects and Warnings
There is insufficient evidence to support the use of krebiozen. Patients should be made aware of the existing treatment options for their specific conditions, particularly treatments with demonstrated efficacy. Pain and mild icterus (jaundice) have been reported. Avoid use in patients with cancer as only negative data has been published.
Pregnancy & Breastfeeding
Kreboizen is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.
Interactions with Drugs
Insufficient available evidence.
Interactions with Herbs & Dietary Supplements
Insufficient available evidence.
This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Julie Conquer, PhD (RGB Consulting); Nicole Giese, MS (Natural Standard Research Collaboration); Dana A. Hackman, BS (Northeastern University); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Shannon Welch, PharmD (Northeastern University); Denise Wong, PharmD (Northeastern University).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Anon. STATUS report on "krebiozen". J Am Med Assoc 1951;147(9):864-873.
Anon. Unproven methods of cancer management. Krebiozen and carcalon. CA Cancer J Clin 1973;23(2):111-115.
Beck M. [Remedies and quackeries]. Acta Pharm Hung 1999;69(1):5-8.
Holland JF. The krebiozen story. Is cancer quackery dead? JAMA 1967;200(3):213-218.
Jallut O, Guex P, Barrelet L. [Unproven methods in oncology]. Schweiz Med Wochenschr 1984;114(36):1214-1220.
Janssen WF. Cancer quackery--the past in the present. Semin Oncol 1979;6(4):526-536.
Langer E. The Krebiozen case: what happened in Chicago. Science 1966;151(714):1061-1064.
Stolinsky DC, Bateman JR. Recurrent masses at sites of prior Krebiozen (NSC-8752) injections. Cancer Chemother Rep 1974;58(2):249-250.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.