Drugs A - Z
Jimson weed (Datura stramonium L.)
Generic Name: Datura
CategoryHerbs & Supplements
Alkaloids, angel's trumpet, apple of peru, atropine, belladonna alkaloids, complex-type oligosaccharide binding lectin, crazy tea, Datura arborea, D. aurea, D. candida, Datura inoxia, Datura L., Datura metel, D. sanguinea, Datura stramonium, Datura stramonium agglutinin, Datura stramonium L. var. tatula (L.) Torr., Datura suaveolens, Datura tatula L., devil's seed, devil's snare, devil's trumpet, DSA, endemic nightshade, hyoscamine, Jamestown weed, jimsonweed, lectins, "loco" weed, mad hatter, malpitte, moonflower seed, nightshade, pods, scopolamine, sobi-lobi, Solanaceae (family), stinkweed, TAL, thorn apple, thornapple leaf, tolguacha, toxic alkaloids, tropane belladonna alkaloids, trumpet lily, zombie's cucumber.
Jimson weed (Datura stramonium) grows throughout the world and has been known as a hallucinogenic plant for centuries. It has reportedly been used by Shamans and native peoples during sacred rituals. In India, the smoke of jimson weed has been used to treat asthma.
Jimson weed may cause extreme toxicity including death. Even very small amounts may cause death. Jimson weed is therefore not used medicinally today, although some alkaloids from jimson weed are approved drugs.
In early research, jimson weed has been studied for asthma and chronic bronchitis, however, clinical evidence supporting any safe or effective use of jimson weed is lacking at this time.
EvidenceDISCLAIMER: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
TraditionWARNING: DISCLAIMER: The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Antibacterial, antimicrobial, antitumor, asthma, colorectal cancer, hallucinogenic, insecticide, muscle spasms, Parkinson's disease (saliva production control), sedative, whooping cough.
Adults (18 years and older)
There is no proven safe or effective dose for jimson weed. Jimson weed may cause extreme toxicity.
Children (under 18 years old)
There is no proven safe or effective dose for jimson weed, and use in children is not recommended. Jimson weed may cause extreme toxicity and even small amounts may cause death in children.
SafetyDISCLAIMER: Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.
Avoid with a known allergy or hypersensitivity to jimson weed, its constituents, other Datura species, or other plants in the nightshade family, such as tobacco, peppers, eggplant, potatoes, and tomatoes.
Side Effects and Warnings
Jimson weed may cause extreme toxicity including death. Even very small amounts may cause death.
Jimson weed may cause rapid heart rate, life threatening abnormal heart rhythm, high blood pressure, respiratory arrest, psychosis, delirium, disorientation, hallucinations, seizures, amnesia, coma, and may worsen neurological disorders.
Jimson weed may increase the risk of bleeding. Caution is advised in patients with bleeding disorders or taking drugs that may increase the risk of bleeding. Dosing adjustments may be necessary.
Jimson weed may also cause liver damage, kidney damage, difficulty urinating or urinary retention, and blurred vision.
Pregnancy and Breastfeeding
Interactions with Drugs
Jimson weed may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).
Jimson weed may increase the amount of drowsiness caused by some drugs. Examples include benzodiazepines such as lorazepam (Ativan®) or diazepam (Valium®), barbiturates such as phenobarbital, narcotics such as codeine, some antidepressants, and alcohol. Caution is advised while driving or operating machinery.
Jimson weed may alter blood pressure. Caution is advised in patients taking drugs that alter blood pressure.
Jimson weed may have additive effects when taken with anti-cholinergics, beta-blockers, cardiac glycosides, antimicrobials, analgesics, antipsychotics, diuretics, stimulants, drugs used for the eye, drugs used to alter heart rate or heart rhythm, drugs toxic to the liver, or drugs with anti-asthmatic, anticancer, anti-seizure, or immune altering properties.
Interactions with Herbs and Dietary Supplements
Jimson weed may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
Jimson weed may increase the amount of drowsiness caused by some herbs or supplements.
Jimson weed may alter blood pressure. Caution is advised in patients taking herbs or supplements that alter blood pressure.
Jimson weed may have additive effects when taken with anti-cholinergics, beta-blockers, alkaloids, cardiac glycosides, antimicrobials, analgesics, antipsychotics, diuretics, stimulants, herbs or supplements used for the eye, herbs or supplements used to alter heart rate or heart rhythm, herbs or supplements toxic to the liver, or herbs or supplements with anti-asthmatic, anticancer, anti-seizure, or immune altering properties.
This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): J. Kathryn Bryan, BA (Natural Standard Research Collaboration); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Cathleen Rapp, ND (private practice; President: Rapp Research); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA, BS (Natural Standard Research Collaboration).
BibliographyDISCLAIMER: Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Alebiowu, G, Femi-Oyewo, MN, Elujoba, AA, et al. Toxicity studies on Datura metel L. with reference to official stramonium. J Herb Pharmacother. 2007;7(1):1-12.
Boumba, VA, Mitselou, A, and Vougiouklakis, T. Fatal poisoning from ingestion of Datura stramonium seeds. Vet Hum Toxicol. 2004;46(2):81-82.
Calbo Mayo, JM, Barba Romero, MA, Broseta, Viana L, et al. [Accidental familiar poisoning by Datura stramonium]. An Med Interna 2004;21(8):415.
Clark, JD. The roadside high: Jimson weed toxicity. Air Med J 2005;24(6):234-237.
Dewitt, MS, Swain, R, and Gibson, LB, Jr. The dangers of jimson weed and its abuse by teenagers in the Kanawha Valley of West Virginia. W V Med J 1997;93(4):182-185.
Dieckhofer, K, Vogel, T, and Meyer-Lindenberg, J. [Datura stramonium as a narcotic]. Nervenarzt 1971;42(8):431-437.
Dominguez, Fuentes B, Asencio, Mendez C, Garcia, Gil D, et al. [Hallucinations and agitation in a meeting of adolescents]. Rev Clin Esp. 2008;208(1):58-59.
Eftekhar, F, Yousefzadi, M, and Tafakori, V. Antimicrobial activity of Datura innoxia and Datura stramonium. Fitoterapia 2005;76(1):118-120.
Forrester, MB. Jimsonweed (Datura stramonium) exposures in Texas, 1998-2004. J Toxicol Environ Health A 2006;69(19):1757-1762.
Kurzbaum, A, Simsolo, C, Kvasha, L, and Blum, A. Toxic delirium due to Datura stramonium. Isr Med Assoc J 2001;3(7):538-539.
Mikolich, JR, Paulson, GW, and Cross, CJ. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann Intern Med. 1975;83(3):321-325.
No authors listed. An alternative medicine treatment for Parkinson's disease: results of a multicenter clinical trial. HP-200 in Parkinson's Disease Study Group. J Altern.Complement Med. 1995;1(3):249-255.
Roblot, F, Montaz, L, Delcoustal, M, et al. [Datura stramonium poisoning: the diagnosis is clinical, treatment is symptomatic]. Rev Med Interne 1995;16(3):187-190.
Steenkamp, PA, Harding, NM, van Heerden, FR, et al. Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry. Forensic Sci Int 10-4-2004;145(1):31-39.
Vanderhoff, BT, and Mosser, KH. Jimson weed toxicity: management of anticholinergic plant ingestion. Am Fam Physician 1992;46(2):526-530.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.